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Volume 47
Issue 12
10.3390/cimb47121003
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Review

Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity

by
Alison Gerhardt
1,†,
Dlen Nanakaliy
1,†,
Harnish D. Shah
1,
Syed Sarfaraz
1,
Charlotte Madigan
1,
Makenna Downing
1,
Robert P. Elliott
1,
Rafid Dipto
1,
Bella Vrapciu
1,
Joseph W. Noetzel
1,
Jessica Armas
1,
Ayesha Ahmed
1,
Marc Potempa
2,
Margaret E. Olson
1,
Lawrence A. Potempa
1 and
Peter C. Hart
1,*
1
College of Science, Health and Pharmacy, Roosevelt University, Schaumburg, IL 60173, USA
2
Acphazin, Inc., Deerfield, IL 60015, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2025, 47(12), 1003; https://doi.org/10.3390/cimb47121003 (registering DOI)
Submission received: 26 October 2025 / Revised: 21 November 2025 / Accepted: 26 November 2025 / Published: 28 November 2025
(This article belongs to the Special Issue Advances in Pharmacotherapeutic Strategies to Prevent Tumor Development, Progression and Treatment Resistance, 2nd Edition)
Review Reports Versions Notes

Abstract

C-reactive protein (CRP) is a well-known acute phase reactant and putative biomarker for advancing and chronically established inflammation. Its biological activity across its multiple isoforms plays various roles in the initiation, potentiation, and resolution of inflammation. Its molecular signaling within the tissue microenvironment regulates cell–cell communication across cell types (e.g., epithelial cells, endothelial cells, fibroblasts, adipocytes, and immune cells) and affects the development of conditions such as cancer that are subject, at least in part, to inflammatory signaling. Considering the dynamic nature of CRP in modulating disease progression, and the growing evidence of the context-dependent direct molecular activity of CRP on regulating intra- and inter-cellular signaling, it is critical to further understand how this integral molecule alters cell signaling pathways. Although the ability of CRP to directly interact with some extracellular matrix proteins involved with inflammation and disease has been reported as early as the mid-1980s, recent advances in unbiased proteomics have revealed a broader interactome of protein–protein interactions (PPIs) involving CRP. The present study evaluates the CRP PPIs identified to date and explores the potential novel regulatory capacity of CRP on multiple key cellular functions in metabolism and cell–cell signaling, offering an updated framework of the possible biological activities of CRP relevant to tumorigenic processes.
Keywords: C-reactive protein; CRP; interactome; protein-protein interactions; glycoproteins; glycosaminoglycan biosynthesis; extracellular matrix; tumor microenvironment C-reactive protein; CRP; interactome; protein-protein interactions; glycoproteins; glycosaminoglycan biosynthesis; extracellular matrix; tumor microenvironment

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MDPI and ACS Style

Gerhardt, A.; Nanakaliy, D.; Shah, H.D.; Sarfaraz, S.; Madigan, C.; Downing, M.; Elliott, R.P.; Dipto, R.; Vrapciu, B.; Noetzel, J.W.; et al. Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity. Curr. Issues Mol. Biol. 2025, 47, 1003. https://doi.org/10.3390/cimb47121003

AMA Style

Gerhardt A, Nanakaliy D, Shah HD, Sarfaraz S, Madigan C, Downing M, Elliott RP, Dipto R, Vrapciu B, Noetzel JW, et al. Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity. Current Issues in Molecular Biology. 2025; 47(12):1003. https://doi.org/10.3390/cimb47121003

Chicago/Turabian Style

Gerhardt, Alison, Dlen Nanakaliy, Harnish D. Shah, Syed Sarfaraz, Charlotte Madigan, Makenna Downing, Robert P. Elliott, Rafid Dipto, Bella Vrapciu, Joseph W. Noetzel, and et al. 2025. "Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity" Current Issues in Molecular Biology 47, no. 12: 1003. https://doi.org/10.3390/cimb47121003

APA Style

Gerhardt, A., Nanakaliy, D., Shah, H. D., Sarfaraz, S., Madigan, C., Downing, M., Elliott, R. P., Dipto, R., Vrapciu, B., Noetzel, J. W., Armas, J., Ahmed, A., Potempa, M., Olson, M. E., Potempa, L. A., & Hart, P. C. (2025). Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity. Current Issues in Molecular Biology, 47(12), 1003. https://doi.org/10.3390/cimb47121003

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