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Volume 43
Issue 2
10.3390/cimb43020064
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Review
Peer-Review Record

Circulating miRNAs Related to Epithelial–Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis

Curr. Issues Mol. Biol. 2021, 43(2), 900-916; https://doi.org/10.3390/cimb43020064
by Anna Zubrzycka 1,*, Monika Migdalska-Sęk 1, Sławomir Jędrzejczyk 2 and Ewa Brzeziańska-Lasota 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Curr. Issues Mol. Biol. 2021, 43(2), 900-916; https://doi.org/10.3390/cimb43020064
Submission received: 4 July 2021 / Revised: 31 July 2021 / Accepted: 3 August 2021 / Published: 5 August 2021
(This article belongs to the Section Molecular Medicine)

Round 1

Reviewer 1 Report

In this interesting review article, the authors have to review the role of miRNA in endometriosis and assessed the possibility of miRNA as a diagnostic biomarker in endometriosis. However, the results of studies seem to be controversial.

Introduction

  1. The pathogenesis of is complicated. The authors wish to review the role of miRNA in endometriosis, however, the author focus to much in other marker, such as TGF-β and VEGF secretion and etc. I suggest the author shorten the introduction and more focus in miRNA.

Candidate genes:

  1. Microarray analyses have identified a large number of mRNA transcripts differentially expressed in the eutopic endometrium of women with endometriosis. It may very interesting to discuss the most potential candidate miRNA genes to explain the mechanisms of endometriosis/EMT.
  2. The prevalence of endometriosis varies, probably associated to different races and different diagnostic criteria, and miRNA as well. Could you explain the relationship of miRNA and races?
  3. Cytokines, which are produced by many cell types including endometriotic tissues, play diverse roles in the pathogenesis of endometriosis. Could you discuss the role on miRNA in cytokines-related endometriosis?

Author Response

Please see the attachment.

Author Response File: Author Response.doc

Reviewer 2 Report

I read with great interest the manuscript, which falls within the aim of this Journal. In my honest opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors should clarify some points and improve the discussion, as suggested below.

Authors should consider the following recommendations:

  • Manuscript should be further revised in order to correct some typos and improve style.
  • Accumulating evidence suggests that immune cells, adhesion molecules, extracellular matrix metalloproteinase and pro-inflammatory cytokines activate/alter peritoneal microenvironment, creating the conditions for differentiation, adhesion, proliferation and survival of ectopic endometrial cells. I would discuss these points in the light of new theories about the pathogenesis of endometriosis, referring to: PMID: 31663401; PMID: 28100109.

Author Response

Please see the attachment.

Author Response File: Author Response.doc

Round 2

Reviewer 1 Report

The revised manuscript is improved a lot and suitable for publication.

 

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