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Volume 28
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10.21775/cimb.028.014
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Snapshots: Endoplasmic Reticulum Stress in Lipid Metabolism and Cardiovascular Disease

by
Tian Li
1,2,†,
Shuai Jiang
3,4,†,
Chenxi Lu
3,†,
Wei Hu
5,
Ting Ji
3,
Mengzhen Han
3,
Yang Yang
2,3,* and
Zhenxiao Jin
1,*
1
Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, China
2
Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
3
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China
4
Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
5
Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2018, 28(1), 14-28; https://doi.org/10.21775/cimb.028.014
Submission received: 8 November 2017 / Revised: 6 December 2017 / Accepted: 3 January 2018 / Published: 1 February 2018

Abstract

The endoplasmic reticulum (ER) is an organelle present in most eukaryotic cells and plays a pivotal role in lipid metabolism. ER dysfunction, specifically ER stress (ERS), is a pathophysiological response involved in lipid metabolism and cardiovascular lesions. Therefore, suppression of ERS may improve lipid metabolic disorders and reduce cardiovascular risk. Herein, we focus on novel breakthroughs regarding the roles of ERS in lipid metabolism and cardiovascular disease (CVD), as well as the internal mechanisms of ERS and its status as a potential therapeutic target. This review highlights recent advances in ERS, the regulation of which might be helpful for both basic research and clinical drug design for lipid metabolic disorders and CVD.
Keywords: snapshots; endoplasmic; reticulum; stress; lipid; metabolism; cardiovascular; disease snapshots; endoplasmic; reticulum; stress; lipid; metabolism; cardiovascular; disease

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MDPI and ACS Style

Li, T.; Jiang, S.; Lu, C.; Hu, W.; Ji, T.; Han, M.; Yang, Y.; Jin, Z. Snapshots: Endoplasmic Reticulum Stress in Lipid Metabolism and Cardiovascular Disease. Curr. Issues Mol. Biol. 2018, 28, 14-28. https://doi.org/10.21775/cimb.028.014

AMA Style

Li T, Jiang S, Lu C, Hu W, Ji T, Han M, Yang Y, Jin Z. Snapshots: Endoplasmic Reticulum Stress in Lipid Metabolism and Cardiovascular Disease. Current Issues in Molecular Biology. 2018; 28(1):14-28. https://doi.org/10.21775/cimb.028.014

Chicago/Turabian Style

Li, Tian, Shuai Jiang, Chenxi Lu, Wei Hu, Ting Ji, Mengzhen Han, Yang Yang, and Zhenxiao Jin. 2018. "Snapshots: Endoplasmic Reticulum Stress in Lipid Metabolism and Cardiovascular Disease" Current Issues in Molecular Biology 28, no. 1: 14-28. https://doi.org/10.21775/cimb.028.014

APA Style

Li, T., Jiang, S., Lu, C., Hu, W., Ji, T., Han, M., Yang, Y., & Jin, Z. (2018). Snapshots: Endoplasmic Reticulum Stress in Lipid Metabolism and Cardiovascular Disease. Current Issues in Molecular Biology, 28(1), 14-28. https://doi.org/10.21775/cimb.028.014

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