Next Article in Journal
High-Dose Ibuprofen in Cystic Fibrosis
Next Article in Special Issue
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Previous Article in Journal
The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling
Previous Article in Special Issue
Cannabinoid-Induced Hyperemesis: A Conundrum—From Clinical Recognition to Basic Science Mechanisms

Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, Japan
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(7), 2197-2212;
Received: 10 June 2010 / Revised: 29 June 2010 / Accepted: 6 July 2010 / Published: 8 July 2010
(This article belongs to the Special Issue Cannabinoids)
Cannabis contains the psychoactive component delta9-tetrahydrocannabinol (delta9-THC), and the non-psychoactive components cannabidiol (CBD), cannabinol, and cannabigerol. It is well-known that delta9-THC and other cannabinoid CB1 receptor agonists are neuroprotective during global and focal ischemic injury. Additionally, delta9-THC also mediates psychological effects through the activation of the CB1 receptor in the central nervous system. In addition to the CB1 receptor agonists, cannabis also contains therapeutically active components which are CB1 receptor independent. Of the CB1 receptor-independent cannabis, the most important is CBD. In the past five years, an increasing number of publications have focused on the discovery of the anti-inflammatory, anti-oxidant, and neuroprotective effects of CBD. In particular, CBD exerts positive pharmacological effects in ischemic stroke and other chronic diseases, including Parkinson’s disease, Alzheimer’s disease, and rheumatoid arthritis. The cerebroprotective action of CBD is CB1 receptor-independent, long-lasting, and has potent anti-oxidant activity. Importantly, CBD use does not lead to tolerance. In this review, we will discuss the therapeutic possibility of CBD as a cerebroprotective agent, highlighting recent pharmacological advances, novel mechanisms, and therapeutic time window of CBD in ischemic stroke. View Full-Text
Keywords: cannabinoids; cannabidiol; ischemic stroke; neuroprotective effect cannabinoids; cannabidiol; ischemic stroke; neuroprotective effect
Show Figures

Figure 1

MDPI and ACS Style

Hayakawa, K.; Mishima, K.; Fujiwara, M. Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke. Pharmaceuticals 2010, 3, 2197-2212.

AMA Style

Hayakawa K, Mishima K, Fujiwara M. Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke. Pharmaceuticals. 2010; 3(7):2197-2212.

Chicago/Turabian Style

Hayakawa, Kazuhide, Kenichi Mishima, and Michihiro Fujiwara. 2010. "Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke" Pharmaceuticals 3, no. 7: 2197-2212.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop