Next Article in Journal
Caenorhabditis elegans as an In Vivo Model for the Discovery and Development of Natural Plant-Based Antimicrobial Compounds
Previous Article in Journal
Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceuticals
Volume 16
Issue 8
10.3390/ph16081068
pharmaceuticals-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

by
Mariana Dalmagro
1,
Mariana Moraes Pinc
1,
Guilherme Donadel
1,
Getulio Capello Tominc
1,
Ezilda Jacomassi
1,
Emerson Luiz Botelho Lourenço
1,
Arquimedes Gasparotto Junior
2,
André Giarola Boscarato
1,
Salviano Tramontin Belettini
1,
Odair Alberton
1,
Inara Staub Prochnau
3,
Reinaldo Aparecido Bariccatti
4,
Rafael Menck de Almeida
5,
Kelen Menezes Flores Rossi de Aguiar
6 and
Jaqueline Hoscheid
1,*
1
Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama 87502-210, Brazil
2
Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79804-970, Brazil
3
School of Medicine and Life Sciences, Pontifical Catholic University of Paraná, Toledo 85902-532, Brazil
4
Center for Engineering and Exact Sciences, State University of Western Paraná, Toledo 85903-220, Brazil
5
Synthetica Research and Technical Analysis Ltda., Capela do Alto, São Paulo 18195-000, Brazil
6
Group of Polymers and Nanostructures, Federal Technological University of Paraná, Toledo 85902-490, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(8), 1068; https://doi.org/10.3390/ph16081068
Submission received: 22 June 2023 / Revised: 23 July 2023 / Accepted: 24 July 2023 / Published: 27 July 2023
(This article belongs to the Section Natural Products)
Browse Figures
Versions Notes

Abstract

Natural products can be used as complements or as alternatives to synthetic drugs. Eugenia uniflora and Tropaeolum majus are natives of Brazil and have antimicrobial, anti-inflammatory, and antioxidant activities. This study aimed to develop a film-forming system (FFS) loaded with plant extracts with the potential for treating microbial infections. E. uniflora and T. majus leaf extracts were prepared and characterized, and the individual and combined antioxidant and antimicrobial activities were evaluated. The FFS was developed with different concentrations of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) and analyzed for physicochemical characteristics. The combination of extracts showed a superior antioxidant effect compared to the individual extracts, justifying the use of the blend. FFS prepared with 4.5% PVA, 4.5% PVP, 7.81% E. uniflora extract, and 3.90% T. majus extract was adhesive, lacked scale formation, presented good malleability, and had a suitable pH for topical application. In addition, the viscosity at rest was satisfactory for maintaining stability; water solubility was adequate; skin permeation was low; and the antimicrobial effect was superior to that of the individual extracts. Therefore, the developed FFS is promising for the differentiated treatment of skin lesions through topical application.
Keywords: polyvinyl alcohol; chaguinha; checkerboard; pitanga; polyvinylpyrrolidone polyvinyl alcohol; chaguinha; checkerboard; pitanga; polyvinylpyrrolidone
Graphical Abstract

Share and Cite

MDPI and ACS Style

Dalmagro, M.; Pinc, M.M.; Donadel, G.; Tominc, G.C.; Jacomassi, E.; Lourenço, E.L.B.; Gasparotto Junior, A.; Boscarato, A.G.; Belettini, S.T.; Alberton, O.; et al. Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions. Pharmaceuticals 2023, 16, 1068. https://doi.org/10.3390/ph16081068

AMA Style

Dalmagro M, Pinc MM, Donadel G, Tominc GC, Jacomassi E, Lourenço ELB, Gasparotto Junior A, Boscarato AG, Belettini ST, Alberton O, et al. Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions. Pharmaceuticals. 2023; 16(8):1068. https://doi.org/10.3390/ph16081068

Chicago/Turabian Style

Dalmagro, Mariana, Mariana Moraes Pinc, Guilherme Donadel, Getulio Capello Tominc, Ezilda Jacomassi, Emerson Luiz Botelho Lourenço, Arquimedes Gasparotto Junior, André Giarola Boscarato, Salviano Tramontin Belettini, Odair Alberton, and et al. 2023. "Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions" Pharmaceuticals 16, no. 8: 1068. https://doi.org/10.3390/ph16081068

APA Style

Dalmagro, M., Pinc, M. M., Donadel, G., Tominc, G. C., Jacomassi, E., Lourenço, E. L. B., Gasparotto Junior, A., Boscarato, A. G., Belettini, S. T., Alberton, O., Prochnau, I. S., Bariccatti, R. A., Almeida, R. M. d., Rossi de Aguiar, K. M. F., & Hoscheid, J. (2023). Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions. Pharmaceuticals, 16(8), 1068. https://doi.org/10.3390/ph16081068

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop