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Volume 16
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Article

Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology

by
Juan Carlos Gomez-Verjan
1,†,
Emmanuel Alejandro Zepeda-Arzate
1,†,
José Alberto Santiago-de-la-Cruz
1,
Edgar Antonio Estrella-Parra
2 and
Nadia Alejandra Rivero-Segura
1,*
1
Dirección de Investigación, Instituto Nacional de Geriatría (INGER), Blvd. Adolfo Ruiz Cortines 2767, Mexico City 10200, Mexico
2
Laboratorio de Fitoquímica, UBIPRO, FES-Iztacala, Unidad Nacional Autónoma de México, Av. De los Barrios No.1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2023, 16(10), 1376; https://doi.org/10.3390/ph16101376
Submission received: 21 August 2023 / Revised: 20 September 2023 / Accepted: 25 September 2023 / Published: 28 September 2023
(This article belongs to the Special Issue Structural and Computational-Driven Molecule Design in Drug Discovery)
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Abstract

Ischemic stroke (IS) is one of the leading causes of mortality worldwide. It is characterized by the partial or total occlusion of arteries that supply blood to the brain, leading to the death of brain cells. In recent years, natural bioactive compounds (NBCs) have shown properties that ameliorate the injury after IS and improve the patient’s outcome, which has proven to be a potential therapeutic strategy due to their neuroprotective effects. Hence, in the present study, we use both systems pharmacology and chemoinformatic analyses to identify which NBCs have the most potential to be used against IS in clinics. Our results identify that flavonoids and terpenoids are the most studied NBCs, and, mainly, salidrosides, ginkgolides A, B, C, and K, cordycepin, curcumin, baicalin, resveratrol, fucose, and cannabidiol, target the main pathological processes occurring in IS. However, the medicinal chemistry properties of such compounds demonstrate that only six fulfill such criteria. However, only cordycepin and salidroside possess properties as leader molecules, suggesting that these compounds may be considered in developing novel drugs against IS.
Keywords: natural bioactive compounds; natural products; network pharmacology; neuroprotection; ischemic stroke; flavonoids; terpenoids natural bioactive compounds; natural products; network pharmacology; neuroprotection; ischemic stroke; flavonoids; terpenoids

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MDPI and ACS Style

Gomez-Verjan, J.C.; Zepeda-Arzate, E.A.; Santiago-de-la-Cruz, J.A.; Estrella-Parra, E.A.; Rivero-Segura, N.A. Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology. Pharmaceuticals 2023, 16, 1376. https://doi.org/10.3390/ph16101376

AMA Style

Gomez-Verjan JC, Zepeda-Arzate EA, Santiago-de-la-Cruz JA, Estrella-Parra EA, Rivero-Segura NA. Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology. Pharmaceuticals. 2023; 16(10):1376. https://doi.org/10.3390/ph16101376

Chicago/Turabian Style

Gomez-Verjan, Juan Carlos, Emmanuel Alejandro Zepeda-Arzate, José Alberto Santiago-de-la-Cruz, Edgar Antonio Estrella-Parra, and Nadia Alejandra Rivero-Segura. 2023. "Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology" Pharmaceuticals 16, no. 10: 1376. https://doi.org/10.3390/ph16101376

APA Style

Gomez-Verjan, J. C., Zepeda-Arzate, E. A., Santiago-de-la-Cruz, J. A., Estrella-Parra, E. A., & Rivero-Segura, N. A. (2023). Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology. Pharmaceuticals, 16(10), 1376. https://doi.org/10.3390/ph16101376

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