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Pharmaceuticals
Volume 16
Issue 1
10.3390/ph16010070
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Article

Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway

by
Xi Wang
1,†,
Gang Shao
1,2,†,
Xiangyu Hong
2,
Yue Shi
2,
Yiting Zheng
2,
Yucheng Yu
2 and
Caiyun Fu
2,3,*
1
Department of Oncology, No.903 Hospital of PLA Joint Logistic Support Force, Hangzhou 310013, China
2
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
3
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2023, 16(1), 70; https://doi.org/10.3390/ph16010070
Submission received: 6 December 2022 / Revised: 27 December 2022 / Accepted: 29 December 2022 / Published: 1 January 2023
(This article belongs to the Special Issue Natural Products as Drug Candidates for Redox-Related Human Disease)
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Abstract

Colon cancer is one of the most common digestive tract malignancies, having the second highest mortality rate among all tumors, with a five-year survival of advanced patients of only 10%. Efficient, targeted drugs are still lacking in treating colon cancer, so it is urgent to explore novel druggable targets. Here, we demonstrated that annexin A1 (ANXA1) was overexpressed in tumors of 50% of colon cancer patients, and ANXA1 overexpression was significantly negatively correlated with the poor prognosis of colon cancer. ANXA1 promoted the abnormal proliferation of colon cancer cells in vitro and in vivo by regulating the cell cycle, while the knockdown of ANXA1 almost totally inhibited the growth of colon cancer cells in vivo. Furthermore, ANXA1 antagonized the autophagic death of honokiol in colon cancer cells via stabilizing mitochondrial reactive oxygen species. Based on these results, we speculated that ANXA1 might be a druggable target to control colon cancer and overcome drug resistance.
Keywords: annexin A1; colon cancer; hyperproliferation; honokiol; autophagy; reactive oxygen species; drug resistance annexin A1; colon cancer; hyperproliferation; honokiol; autophagy; reactive oxygen species; drug resistance

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MDPI and ACS Style

Wang, X.; Shao, G.; Hong, X.; Shi, Y.; Zheng, Y.; Yu, Y.; Fu, C. Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway. Pharmaceuticals 2023, 16, 70. https://doi.org/10.3390/ph16010070

AMA Style

Wang X, Shao G, Hong X, Shi Y, Zheng Y, Yu Y, Fu C. Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway. Pharmaceuticals. 2023; 16(1):70. https://doi.org/10.3390/ph16010070

Chicago/Turabian Style

Wang, Xi, Gang Shao, Xiangyu Hong, Yue Shi, Yiting Zheng, Yucheng Yu, and Caiyun Fu. 2023. "Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway" Pharmaceuticals 16, no. 1: 70. https://doi.org/10.3390/ph16010070

APA Style

Wang, X., Shao, G., Hong, X., Shi, Y., Zheng, Y., Yu, Y., & Fu, C. (2023). Targeting Annexin A1 as a Druggable Player to Enhance the Anti-Tumor Role of Honokiol in Colon Cancer through Autophagic Pathway. Pharmaceuticals, 16(1), 70. https://doi.org/10.3390/ph16010070

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