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Pharmaceuticals, Volume 16, Issue 1

January 2023 - 133 articles

Cover Story:

Nanosystems such as liposomes, ethosomes, transferosomes, and bilosomes (BS) have shown promising results in dermal drug delivery. Nonetheless, despite the interest of the cosmetic market in naturally derived skin care products, the promising potential of marine-derived natural products as a source for active compounds with antiaging effects has remained relatively undiscovered until recently.

Heretofore, a few studies have aimed to study and demonstrate the effect of a nano-platform incorporating SPR. To our knowledge, there have been no reports for SPR nanoformulation effects on ultraviolet B-mediated skin aging. Thus, the aim of this study is to develop a novel topically applied antiaging nanodelivery system encapsulating SPR, followed by in vitro and in vivo assessment to confirm the superior efficacy of this novel nanoplatform. View this paper

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Articles (133)

  • Article
  • Open Access
1 Citations
5,474 Views
11 Pages
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Evaluation of Safety, Tolerability and Pharmacokinetic Characteristics of SA001 and Its Active Metabolite Rebamipide after Single and Multiple Oral Administration

  • Sungyeun Bae,
  • Ki Young Huh,
  • Jaeseong Oh,
  • Kyung-Sang Yu and
  • Anhye Kim
Pharmaceuticals2023, 16(1), 132;https://doi.org/10.3390/ph16010132

16 January 2023

Dry eye disease (DED) is one of the most common eye diseases caused by multiple factors. Rebamipide, which is currently used to treat peptic ulcer disease, was shown to enhance secretory function and modulate inflammation in animal disease models. Co...

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  • Article
  • Open Access
14 Citations
5,307 Views
17 Pages
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Exploration of the Antioxidant and Anti-inflammatory Potential of Cassia sieberiana DC and Piliostigma thonningii (Schumach.) Milne-Redh, Traditionally Used in the Treatment of Hepatitis in the Hauts-Bassins Region of Burkina Faso

  • Eliasse Zongo,
  • Anna Busuioc,
  • Roland Nâg-Tiero Meda,
  • Andreea Veronica Botezatu,
  • Maria Daniela Mihaila,
  • Ana-Maria Mocanu,
  • Sorin Marius Avramescu,
  • Benjamin Kouliga Koama,
  • Sami Eric Kam and
  • Hadidiatou Belem
  • + 4 authors
Pharmaceuticals2023, 16(1), 133;https://doi.org/10.3390/ph16010133

16 January 2023

Inflammation is the supreme biological response to illness. In the Hauts-Bassins region, in traditional medicine, all parts of Cassia sieberiana and Piliostigma thonningii are used to treat hepatitis and inflammation. The aim of this study was to eva...

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  • Article
  • Open Access
8 Citations
3,634 Views
23 Pages
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N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agents—In Silico and In Vitro Evaluation

  • Anthi Petrou,
  • Athina Geronikaki,
  • Victor Kartsev,
  • Antonios Kousaxidis,
  • Aliki Papadimitriou-Tsantarliotou,
  • Marina Kostic,
  • Marija Ivanov,
  • Marina Sokovic,
  • Ioannis Nicolaou and
  • Ioannis S. Vizirianakis
Pharmaceuticals2023, 16(1), 131;https://doi.org/10.3390/ph16010131

16 January 2023

Herein, we report the experimental evaluation of the antimicrobial activity of seventeen new (Z)-methyl 3-(4-oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylate derivatives. All tested compounds exhibited antibacterial activity against...

Full Article
  • Systematic Review
  • Open Access
52 Citations
38,444 Views
15 Pages
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RETRACTED: Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis

  • Christiano Argano,
  • Raffaella Mallaci Bocchio,
  • Giuseppe Natoli,
  • Salvatore Scibetta,
  • Marika Lo Monaco and
  • Salvatore Corrao
Pharmaceuticals2023, 16(1), 130;https://doi.org/10.3390/ph16010130

16 January 2023

Background: The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin D plays a cru...

Full Article
  • Article
  • Open Access
5 Citations
4,994 Views
25 Pages
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Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice

  • Carolina Marcucci,
  • Marina Rademacher,
  • Fabiola Kamecki,
  • Valentina Pastore,
  • Hernán Gerónimo Bach,
  • Rafael Alejandro Ricco,
  • Marcelo Luis Wagner,
  • Damijan Knez,
  • Stanislav Gobec and
  • Natalia Colettis
  • + 1 author
Pharmaceuticals2023, 16(1), 129;https://doi.org/10.3390/ph16010129

16 January 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we pr...

Full Article
  • Article
  • Open Access
25 Citations
4,757 Views
17 Pages
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Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

  • Rofida Albash,
  • Noha M. Badawi,
  • Mohammed I. A. Hamed,
  • Maha H. Ragaie,
  • Sahar S. Mohammed,
  • Rovan M. Elbesh,
  • Khaled M. Darwish,
  • Manar O. Lashkar,
  • Sameh S. Elhady and
  • Shaimaa Mosallam
Pharmaceuticals2023, 16(1), 128;https://doi.org/10.3390/ph16010128

15 January 2023

The foremost target of the current work was to formulate and optimize a novel bergamot essential oil (BEO) loaded nano-phytosomes (NPs) and then combine it with spironolactone (SP) in order to clinically compare the efficiency of both formulations ag...

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  • Article
  • Open Access
6 Citations
3,390 Views
24 Pages
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SIRT2i_Predictor: A Machine Learning-Based Tool to Facilitate the Discovery of Novel SIRT2 Inhibitors

  • Nemanja Djokovic,
  • Minna Rahnasto-Rilla,
  • Nikolaos Lougiakis,
  • Maija Lahtela-Kakkonen and
  • Katarina Nikolic
Pharmaceuticals2023, 16(1), 127;https://doi.org/10.3390/ph16010127

14 January 2023

A growing body of preclinical evidence recognized selective sirtuin 2 (SIRT2) inhibitors as novel therapeutics for treatment of age-related diseases. However, none of the SIRT2 inhibitors have reached clinical trials yet. Transformative potential of...

Full Article
  • Review
  • Open Access
32 Citations
14,667 Views
24 Pages
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Terminalia arjuna, a Cardioprotective Herbal Medicine–Relevancy in the Modern Era of Pharmaceuticals and Green Nanomedicine—A Review

  • Purnimajayasree Ramesh and
  • Arunkumar Palaniappan
Pharmaceuticals2023, 16(1), 126;https://doi.org/10.3390/ph16010126

13 January 2023

Herbal medicines were the main source of therapeutic agents in the ancestral era. Terminalia arjuna (TA) is one such medicinal plant widely known for its several medicinal properties, especially its cardiovascular properties. They have several phytoc...

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  • Article
  • Open Access
12 Citations
4,375 Views
22 Pages
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Novel Benzimidazole Derived Imine Ligand and Its Co(III) and Cu(II) Complexes as Anticancer Agents: Chemical Synthesis, DFT Studies, In Vitro and In Vivo Biological Investigations

  • Prakasha G,
  • H. D. Revanasiddappa,
  • Jayalakshmi B,
  • Prabhakar B. T,
  • Chandan Shivamallu,
  • Prashant M. Viswanath,
  • Raghu Ram Achar,
  • Ekaterina Silina,
  • Victor Stupin and
  • Natalia Manturova
  • + 6 authors
Pharmaceuticals2023, 16(1), 125;https://doi.org/10.3390/ph16010125

13 January 2023

The emerging interest in the field of coordination chemistry and their biological applications has created a novel impact in the field of chemical biology. With this motivation, in this work we have synthesized a novel benzimidazole derived imine lig...

Full Article
  • Article
  • Open Access
4 Citations
3,763 Views
12 Pages
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Established Immortalized Cavernous Endothelial Cells Improve Erectile Dysfunction in Rats with Cavernous Nerve Injury

  • Sang Hong Bak,
  • Jae Heon Kim,
  • Seung U. Kim,
  • Dong-Seok Lee,
  • Yun Seob Song and
  • Hong J. Lee
Pharmaceuticals2023, 16(1), 123;https://doi.org/10.3390/ph16010123

13 January 2023

The main cause of erectile dysfunction (ED) is the damage in penile cavernous endothelial cells (EC). Murine primary ECs have a limited growth potential, and the easy availability of murine ECs will facilitate the study of cavernous endothelial dysfu...

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