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Pharmaceuticals
Volume 16
Issue 1
10.3390/ph16010036
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Article

Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage

by
Mariam Zewail
1,
Passent M. E. Gaafar
2,
Nancy Abdel Hamid Abou Youssef
3,
Merhan E. Ali
4,
Mai F. Ragab
5,
Miranda F. Kamal
6,
Mohamed H. Noureldin
7 and
Haidy Abbas
1,*
1
Pharmaceutics Department, Faculty of Pharmacy, Damanhour University, Damanhour P.O. Box 22511, Egypt
2
Department of Pharmaceutics, Division of Pharmaceutical Sciences, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria P.O. Box 1029, Egypt
3
Department of Pharmaceutics, Faculty of Pharmacy, Pharos University in Alexandria (PUA), Alexandria P.O. Box 21500, Egypt
4
Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza P.O. Box 12211, Egypt
5
Pharmacology Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo P.O. Box 11835, Egypt
6
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Damanhour University, Damanhour P.O. Box 22511, Egypt
7
Department of Biochemistry, Division of Clinical and Biological Sciences, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria P.O. Box 1029, Egypt
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(1), 36; https://doi.org/10.3390/ph16010036
Submission received: 28 November 2022 / Revised: 16 December 2022 / Accepted: 23 December 2022 / Published: 27 December 2022
(This article belongs to the Section Pharmaceutical Technology)
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Abstract

The recent interest in bioactive compounds from natural sources has led to the evolution of the skin care industry. Efforts to develop biologically active ingredients from natural sources have resulted in the emergence of enhanced skin care products. Spirulina (SPR), a nutritionally enriched cyanobacteria-type microalga, is rich in nutrients and phytochemicals. SPR possesses antioxidant, immunomodulatory, and anti-inflammatory activities. Spirulina-loaded bilosomes (SPR-BS), a novel antiaging drug delivery system, were designed for the first time by incorporation in a lecithin–bile salt-integrated system for bypassing skin delivery obstacles. The optimized BS had good entrapment efficiency, small particle size, optimal zeta potential, and sustained drug release pattern. Blank and SPR-loaded BS formulations were safe, with a primary irritancy index of <2 based on the Draize test. In vivo tests were conducted, and photoprotective antiaging effects were evaluated visually and biochemically by analyzing antioxidant, anti-inflammatory, and anti-wrinkling markers following ultraviolet (UV) B irradiation. Results of biochemical marker analysis and histopathological examination confirmed the superior antiaging effect of SPR-BS compared with SPR. Thus, SPR-loaded BS is a promising nanoplatform for SPR delivery, can be used for treating UV-induced skin damage, and offers maximum therapeutic outcomes.
Keywords: bilosome; Spirulina; antiaging; ultraviolet B skin damage; skin delivery bilosome; Spirulina; antiaging; ultraviolet B skin damage; skin delivery

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MDPI and ACS Style

Zewail, M.; Gaafar, P.M.E.; Youssef, N.A.H.A.; Ali, M.E.; Ragab, M.F.; Kamal, M.F.; Noureldin, M.H.; Abbas, H. Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage. Pharmaceuticals 2023, 16, 36. https://doi.org/10.3390/ph16010036

AMA Style

Zewail M, Gaafar PME, Youssef NAHA, Ali ME, Ragab MF, Kamal MF, Noureldin MH, Abbas H. Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage. Pharmaceuticals. 2023; 16(1):36. https://doi.org/10.3390/ph16010036

Chicago/Turabian Style

Zewail, Mariam, Passent M. E. Gaafar, Nancy Abdel Hamid Abou Youssef, Merhan E. Ali, Mai F. Ragab, Miranda F. Kamal, Mohamed H. Noureldin, and Haidy Abbas. 2023. "Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage" Pharmaceuticals 16, no. 1: 36. https://doi.org/10.3390/ph16010036

APA Style

Zewail, M., Gaafar, P. M. E., Youssef, N. A. H. A., Ali, M. E., Ragab, M. F., Kamal, M. F., Noureldin, M. H., & Abbas, H. (2023). Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage. Pharmaceuticals, 16(1), 36. https://doi.org/10.3390/ph16010036

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