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Review

Hybrid Molecules as Potential Drugs for the Treatment of HIV: Design and Applications

1
African Genome Center, Mohammed VI Polytechnic University, Ben Guerir 43150, Morocco
2
Department of Chemistry, Faculty of Sciences Semlalia, BP 2390, Marrakech 40000, Morocco
*
Author to whom correspondence should be addressed.
Academic Editors: Parvesh Singh and Vipan Kumar
Pharmaceuticals 2022, 15(9), 1092; https://doi.org/10.3390/ph15091092
Received: 7 August 2022 / Revised: 23 August 2022 / Accepted: 26 August 2022 / Published: 31 August 2022
(This article belongs to the Special Issue Hybrid Drugs: Design and Applications)
Human immunodeficiency virus (HIV) infection is a major problem for humanity because HIV is constantly changing and developing resistance to current drugs. This necessitates the development of new anti-HIV drugs that take new approaches to combat an ever-evolving virus. One of the promising alternatives to combination antiretroviral therapy (cART) is the molecular hybrid strategy, in which two or more pharmacophore units of bioactive scaffolds are combined into a single molecular structure. These hybrid structures have the potential to have higher efficacy and lower toxicity than their parent molecules. Given the potential advantages of the hybrid molecular approach, the development and synthesis of these compounds are of great importance in anti-HIV drug discovery. This review focuses on the recent development of hybrid compounds targeting integrase (IN), reverse transcriptase (RT), and protease (PR) proteins and provides a brief description of their chemical structures, structure–activity relationship, and binding mode. View Full-Text
Keywords: anti-HIV; hybrid compounds; multi-targeting; reverse transcriptase; integrase; protease; molecular docking; MD simulations; pharmacophore; structure activity relationship anti-HIV; hybrid compounds; multi-targeting; reverse transcriptase; integrase; protease; molecular docking; MD simulations; pharmacophore; structure activity relationship
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MDPI and ACS Style

Liman, W.; Ait Lahcen, N.; Oubahmane, M.; Hdoufane, I.; Cherqaoui, D.; Daoud, R.; El Allali, A. Hybrid Molecules as Potential Drugs for the Treatment of HIV: Design and Applications. Pharmaceuticals 2022, 15, 1092. https://doi.org/10.3390/ph15091092

AMA Style

Liman W, Ait Lahcen N, Oubahmane M, Hdoufane I, Cherqaoui D, Daoud R, El Allali A. Hybrid Molecules as Potential Drugs for the Treatment of HIV: Design and Applications. Pharmaceuticals. 2022; 15(9):1092. https://doi.org/10.3390/ph15091092

Chicago/Turabian Style

Liman, Wissal, Nouhaila Ait Lahcen, Mehdi Oubahmane, Ismail Hdoufane, Driss Cherqaoui, Rachid Daoud, and Achraf El Allali. 2022. "Hybrid Molecules as Potential Drugs for the Treatment of HIV: Design and Applications" Pharmaceuticals 15, no. 9: 1092. https://doi.org/10.3390/ph15091092

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