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Volume 15
Issue 9
10.3390/ph15091037
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Article

An Evaluation of the Drug Permeability Properties of Human Cadaveric In Situ Tympanic and Round Window Membranes

by
Joachim G. S. Veit
1,2,
Bhaskar Birru
1,2,
Yong Wang
3,
Ruby Singh
1,2,
Elizabeth M. Arrigali
1,2,
Ryan Park
3,
Briggs Miller
3,
Matthew A. Firpo
3,
Albert H. Park
3 and
Monica A. Serban
1,2,*
1
Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA
2
Montana Biotechnology Center (BIOTECH), University of Montana, Missoula, MT 59812, USA
3
Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2022, 15(9), 1037; https://doi.org/10.3390/ph15091037
Submission received: 1 August 2022 / Revised: 19 August 2022 / Accepted: 19 August 2022 / Published: 23 August 2022
(This article belongs to the Special Issue Drug-induced Ototoxicity: Mechanisms and Otoprotective Strategies)
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Abstract

It is estimated that hearing loss currently affects more than 1.5 billion people, or approximately 20% of the global population; however, presently, there are no Food and Drug Administration-approved therapeutics or prophylactics for this condition. While continued research on the development of otoprotective drugs to target this clear unmet need is an obvious path, there are numerous challenges to translating promising therapeutic candidates into human clinical testing. The screening of promising drug candidates relies exclusively on preclinical models. Current models do not permit the rapid high-throughput screening of promising drug candidates, and their relevance to clinical scenarios is often ambiguous. With the current study, we seek to understand the drug permeability properties of the cadaveric tympanic and round window membranes with the goal of generating knowledge that could inform the design and/or evaluation of in vitro organotypic models. The development of such models could enable the early high-throughput screening of topical therapeutic candidates and should address some of the limitations of currently used animal models.
Keywords: temporal bone; tympanic membrane; round window membrane; drug diffusion temporal bone; tympanic membrane; round window membrane; drug diffusion

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MDPI and ACS Style

Veit, J.G.S.; Birru, B.; Wang, Y.; Singh, R.; Arrigali, E.M.; Park, R.; Miller, B.; Firpo, M.A.; Park, A.H.; Serban, M.A. An Evaluation of the Drug Permeability Properties of Human Cadaveric In Situ Tympanic and Round Window Membranes. Pharmaceuticals 2022, 15, 1037. https://doi.org/10.3390/ph15091037

AMA Style

Veit JGS, Birru B, Wang Y, Singh R, Arrigali EM, Park R, Miller B, Firpo MA, Park AH, Serban MA. An Evaluation of the Drug Permeability Properties of Human Cadaveric In Situ Tympanic and Round Window Membranes. Pharmaceuticals. 2022; 15(9):1037. https://doi.org/10.3390/ph15091037

Chicago/Turabian Style

Veit, Joachim G. S., Bhaskar Birru, Yong Wang, Ruby Singh, Elizabeth M. Arrigali, Ryan Park, Briggs Miller, Matthew A. Firpo, Albert H. Park, and Monica A. Serban. 2022. "An Evaluation of the Drug Permeability Properties of Human Cadaveric In Situ Tympanic and Round Window Membranes" Pharmaceuticals 15, no. 9: 1037. https://doi.org/10.3390/ph15091037

APA Style

Veit, J. G. S., Birru, B., Wang, Y., Singh, R., Arrigali, E. M., Park, R., Miller, B., Firpo, M. A., Park, A. H., & Serban, M. A. (2022). An Evaluation of the Drug Permeability Properties of Human Cadaveric In Situ Tympanic and Round Window Membranes. Pharmaceuticals, 15(9), 1037. https://doi.org/10.3390/ph15091037

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