Next Article in Journal
Current Therapies in Clinical Trials of Parkinson’s Disease: A 2021 Update
Next Article in Special Issue
Antiviral Therapeutic Approaches for SARS-CoV-2 Infection: A Systematic Review
Previous Article in Journal
Red Algal Sulfated Galactan Binds and Protects Neural Cells from HIV-1 gp120 and Tat
Previous Article in Special Issue
Identification of SARS-CoV-2 E Channel Blockers from a Repurposed Drug Library
Article

Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1

1
Laboratoire Inflammation Tissus Epithéliaux et Cytokines (LITEC EA 4331), Université de Poitiers, CEDEX 9, 86073 Poitiers, France
2
Laboratoire de Virologie et Mycobactériologie, CHU de Poitiers, 86021 Poitiers, France
3
Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 143-701, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Zoidis Grigoris
Pharmaceuticals 2021, 14(8), 715; https://doi.org/10.3390/ph14080715
Received: 24 June 2021 / Revised: 20 July 2021 / Accepted: 21 July 2021 / Published: 24 July 2021
(This article belongs to the Special Issue Antiviral Drugs 2021)
Hg-CATH and Pb-CATH4 are cathelicidins from Heterocephalus glaber and Python bivittatus that have been previously identified as potent antibacterial peptides. However, their antiviral properties were not previously investigated. In this study, their activity against the herpes simplex virus (HSV)-1 was evaluated during primary human keratinocyte infection. Both of them significantly reduced HSV-1 DNA replication and production of infectious viral particles in keratinocytes at noncytotoxic concentrations, with the stronger activity of Pb-CATH4. These peptides did not show direct virucidal activity and did not exhibit significant immunomodulatory properties, except for Pb-CATH4, which exerted a moderate proinflammatory action. All in all, our results suggest that Hg-CATH and Pb-CATH4 could be potent candidates for the development of new therapies against HSV-1. View Full-Text
Keywords: Hg-CATH; Pb-CATH4; herpes simplex virus I; keratinocytes; antiviral Hg-CATH; Pb-CATH4; herpes simplex virus I; keratinocytes; antiviral
Show Figures

Figure 1

MDPI and ACS Style

Damour, A.; Garcia, M.; Cho, H.-S.; Larivière, A.; Lévêque, N.; Park, C.; Bodet, C. Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1. Pharmaceuticals 2021, 14, 715. https://doi.org/10.3390/ph14080715

AMA Style

Damour A, Garcia M, Cho H-S, Larivière A, Lévêque N, Park C, Bodet C. Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1. Pharmaceuticals. 2021; 14(8):715. https://doi.org/10.3390/ph14080715

Chicago/Turabian Style

Damour, Alexia, Magali Garcia, Hye-Sun Cho, Andy Larivière, Nicolas Lévêque, Chankyu Park, and Charles Bodet. 2021. "Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1" Pharmaceuticals 14, no. 8: 715. https://doi.org/10.3390/ph14080715

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop