Review Reports

Round 1

Reviewer 1 Report

The authors propose an elegant new method of signal detection for drug interactions (Concomitant Signal Score), improving it as compared with the “traditional” Combination Risk Ratio method. The CSS method improves the drug interaction signal detection for a number of cases ≥3 with a good accuracy compared to CRR, even if still low as compared with the Ω shrinkage measure method. The manuscript is relevant and well-written. There seems to be a typographic error in the body of the text, though: the upper limit for the PRR for single drugs is given as PRR₀₂₅ instead of PRR₉₇₅, as mentioned in the figure legends.

Author Response

Reviewer #1

We thank the reviewer for the constructive opinion.

We made all necessary changes to the referee and highlighted them in the manuscript (yellow).

 

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and PRR₀₂₅ drug D₁ (or PRR₀₂₅ drug D₂).　→　and PRR₉₇₅ drug D₁ (or PRR₉₇₅ drug D₂).

Author Response File: Author Response.docx

Reviewer 2 Report

The authors present a well-written manuscript with a new detection criteria for detecting drug-drug interaction trhough the proportional reporting ratio algorithm. I did not find any area where major revision was required. 

Author Response

Reviewer #2

We thank you for the proper review.