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Open AccessArticle

Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study

1
Justus-Liebig-University Giessen, Giessen, c/o NeuroCode AG, D-35578 Wetzlar, Germany
2
NeuroCode AG, D-35578 Wetzlar, Germany
3
Phytomed AB, Bofinkvagen 1, 31275 Vaxtorp, Sweden
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(3), 45; https://doi.org/10.3390/ph13030045
Received: 27 February 2020 / Revised: 11 March 2020 / Accepted: 11 March 2020 / Published: 14 March 2020
(This article belongs to the Special Issue Medicinal Plants 2020)
Background: The current and potential uses of adaptogens are mainly related to treatment of stress-induced fatigue, impaired cognitive function, mental illness, and behavioral- and age-related disorders. However, clinical evidence regarding the efficacy of adaptogens is limited. The primary aim of this study is to determine whether a combination of adaptogenic plant extracts from Andrographis paniculata and Withania somnifera (Adaptra® Forte) could be used as effective and safe treatment for impaired cognitive, memory, or learning ability functions and sleep disorders. Methods: The changes in electroencephalogram (EEG) frequency ranges in 17 different brain regions, psychometric tests of cognitive performance, as well as standard questionnaires of assessment of mood and sleep were measured after single and repeated administration of Adaptra® or placebo for four weeks and after a two-week treatment-free follow-up period within a randomized, double-blind, placebo-controlled two-armed cross-over study. Results: Adaptra® Forte significantly improved cognitive performance in the d2-Test for attention and the concentration performance test after four weeks’ treatment, and was positively correlated with increases in δ and θ power in the quantitative EEG compared with placebo during cognitive challenges. Conclusion: The results of this study suggest that Adaptra® Forte exhibits a calming and anxiolytic effect without sedation, and is associated with overall stress-protective activity. View Full-Text
Keywords: elderly subjects; cognition; Andrographis paniculata; Withania somnifera; adaptogens; quantitative EEG; sleep; psychometry; discriminant analysis elderly subjects; cognition; Andrographis paniculata; Withania somnifera; adaptogens; quantitative EEG; sleep; psychometry; discriminant analysis
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MDPI and ACS Style

Dimpfel, W.; Schombert, L.; Keplinger-Dimpfel, I.K.; Panossian, A. Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study. Pharmaceuticals 2020, 13, 45.

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