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Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview

Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, 140013 Chía, Colombia
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Pharmaceuticals 2020, 13(3), 42; https://doi.org/10.3390/ph13030042
Received: 31 January 2020 / Revised: 27 February 2020 / Accepted: 1 March 2020 / Published: 6 March 2020
(This article belongs to the Collection The Story of Successful Drugs and Recent FDA-Approved Molecules)
Colistin is used as a last-line antibiotic for the treatment of Gram-negative multiresistant bacteria. Due to its high nephrotoxicity, Therapeutic Drug Monitoring (TDM) is recommended for dose adjustment. We aimed to evaluate the available evidence of TDM in patients given colistin to treat Gram-negative infections. In this paper, we offer an overview, using an electronic search of the literature (published up to June 2019, without language restrictions) that compares the clinical outcomes and measurements of colistin TDM. Ultimately, the Therapeutic Drug Monitoring (TDM) of colistin in Plasma could prevent nephrotoxicity risk. View Full-Text
Keywords: Therapeutic Drug Monitoring (TDM); colistin; multiresistant bacteria Therapeutic Drug Monitoring (TDM); colistin; multiresistant bacteria
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Avila, M.-P.; Pacheco, T.; Arias, S.; Bustos, R.-H.; Garcia, J.-C.; Jaimes, D. Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview. Pharmaceuticals 2020, 13, 42.

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