Next Article in Journal
Fatty Acid Amides Synthesized from Andiroba Oil (Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic Option
Previous Article in Journal
Opipramol Inhibits Lipolysis in Human Adipocytes without Altering Glucose Uptake and Differently from Antipsychotic and Antidepressant Drugs with Adverse Effects on Body Weight Control
Previous Article in Special Issue
2019 FDA TIDES (Peptides and Oligonucleotides) Harvest
Open AccessBrief Report

Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview

Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, 140013 Chía, Colombia
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(3), 42;
Received: 31 January 2020 / Revised: 27 February 2020 / Accepted: 1 March 2020 / Published: 6 March 2020
(This article belongs to the Collection The Story of Successful Drugs and Recent FDA-Approved Molecules)
Colistin is used as a last-line antibiotic for the treatment of Gram-negative multiresistant bacteria. Due to its high nephrotoxicity, Therapeutic Drug Monitoring (TDM) is recommended for dose adjustment. We aimed to evaluate the available evidence of TDM in patients given colistin to treat Gram-negative infections. In this paper, we offer an overview, using an electronic search of the literature (published up to June 2019, without language restrictions) that compares the clinical outcomes and measurements of colistin TDM. Ultimately, the Therapeutic Drug Monitoring (TDM) of colistin in Plasma could prevent nephrotoxicity risk. View Full-Text
Keywords: Therapeutic Drug Monitoring (TDM); colistin; multiresistant bacteria Therapeutic Drug Monitoring (TDM); colistin; multiresistant bacteria
Show Figures

Figure 1

MDPI and ACS Style

Avila, M.-P.; Pacheco, T.; Arias, S.; Bustos, R.-H.; Garcia, J.-C.; Jaimes, D. Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview. Pharmaceuticals 2020, 13, 42.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop