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Review

Nanotechnology for the Treatment of Allergic Conjunctival Diseases

1
Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore
2
Department of Cornea and External Eye Disease, Singapore National Eye Centre, Singapore 168751, Singapore
3
Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore
4
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore
5
Ocular Therapeutics and Drug Delivery Group, Singapore Eye Research Institute, Singapore 169856, Singapore
6
Department of Glaucoma, Singapore National Eye Centre, Singapore 168751, Singapore
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(11), 351; https://doi.org/10.3390/ph13110351
Received: 30 September 2020 / Revised: 26 October 2020 / Accepted: 27 October 2020 / Published: 29 October 2020
(This article belongs to the Special Issue Advances in Ocular Pharmacology)
Allergic conjunctivitis is one of the most common external eye diseases and the prevalence has been increasing. The mainstay of treatment is topical eye drops. However, low bioavailability, low ocular drug penetration, transient resident time on the ocular surface due to tear turnover, frequent topical applications and dependence on patient compliance, are the main drawbacks associated with topical administration. Nanotechnology-based medicine has emerged to circumvent these limitations, by encapsulating the drugs and preventing them from degradation and therefore providing sustained and controlled release. Using a nanotechnology-based approach to load the drug is particularly useful for the delivery of hydrophobic drugs such as immunomodulatory agents, which are commonly used in allergic conjunctival diseases. In this review, different nanotechnology-based drug delivery systems, including nanoemulsions, liposomes, nanomicelles, nanosuspension, polymeric and lipid nanoparticles, and their potential ophthalmic applications, as well as advantages and disadvantages, are discussed. We also summarize the results of present studies on the loading of immunomodulators or nonsteroidal anti-inflammatory drugs to nano-scaled drug delivery systems. For future potential clinical use, research should focus on the optimization of drug delivery designs that provide adequate and effective doses with safe and satisfactory pharmacokinetic and pharmaco-toxic profiles. View Full-Text
Keywords: allergic eye diseases; nanomedicine; drug delivery system allergic eye diseases; nanomedicine; drug delivery system
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MDPI and ACS Style

Liu, Y.-C.; Lin, M.T.-Y.; Ng, A.H.C.; Wong, T.T.; Mehta, J.S. Nanotechnology for the Treatment of Allergic Conjunctival Diseases. Pharmaceuticals 2020, 13, 351. https://doi.org/10.3390/ph13110351

AMA Style

Liu Y-C, Lin MT-Y, Ng AHC, Wong TT, Mehta JS. Nanotechnology for the Treatment of Allergic Conjunctival Diseases. Pharmaceuticals. 2020; 13(11):351. https://doi.org/10.3390/ph13110351

Chicago/Turabian Style

Liu, Yu-Chi, Molly T.-Y. Lin, Anthony H.C. Ng, Tina T. Wong, and Jodhbir S. Mehta 2020. "Nanotechnology for the Treatment of Allergic Conjunctival Diseases" Pharmaceuticals 13, no. 11: 351. https://doi.org/10.3390/ph13110351

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