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Open AccessFeature PaperArticle

Role of the Metal Center in the Modulation of the Aggregation Process of Amyloid Model Systems by Square Planar Complexes Bearing 2-(2'-pyridyl)benzimidazole Ligands

1
Department of Pharmacy, University of Naples Federico II, Napoli 80134, Italy
2
Department of Chemical Sciences, University of Naples Federico II, Napoli 80126, Italy
3
CEINGE Biotecnologie Avanzate S.c.a r.l., University of Naples Federico II, Napoli 80145, Italy
4
Department of Chemistry Ugo Schiff, University of Florence, Sesto Fiorentino (FI) 50019, Italy
5
Department of Chemistry, Faculty of Science, University of Cairo, Gamma street, Giza, 12613, Egypt
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(4), 154; https://doi.org/10.3390/ph12040154
Received: 13 September 2019 / Revised: 9 October 2019 / Accepted: 10 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue Metal-Based Drugs: Updates and Perspectives)
The effect of analogue Pd(II)-, Pt(II)-, and Au(III) compounds featuring 2-(2’-pyridyl)benzimidazole on the aggregation propensity of amyloid-like peptides derived from Aβ and from the C-terminal domain of nucleophosmin 1 was investigated. Kinetic profiles of aggregation were evaluated using thioflavin binding assays, whereas the interactions of the compounds with the peptides were studied by UV-Vis absorption spectroscopy and electrospray ionization mass spectrometry. The results indicate that the compounds modulate the aggregation of the investigated peptides using different mechanisms, suggesting that the reactivity of the metal center and the physicochemical properties of the metals (rather than those of the ligands and the geometry of the metal compounds) play a crucial role in determining the anti-aggregation properties.
Keywords: amyloid aggregation; metallodrugs; gold(III) compounds; platinum(II) compounds; palladium(II) compounds; anti-aggregation properties amyloid aggregation; metallodrugs; gold(III) compounds; platinum(II) compounds; palladium(II) compounds; anti-aggregation properties
MDPI and ACS Style

Florio, D.; Iacobucci, I.; Ferraro, G.; Mansour, A.M.; Morelli, G.; Monti, M.; Merlino, A.; Marasco, D. Role of the Metal Center in the Modulation of the Aggregation Process of Amyloid Model Systems by Square Planar Complexes Bearing 2-(2'-pyridyl)benzimidazole Ligands. Pharmaceuticals 2019, 12, 154.

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