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Open AccessFeature PaperReview

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview

School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, 62032 Camerino, MC, Italy
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Pharmaceuticals 2019, 12(4), 150; https://doi.org/10.3390/ph12040150
Received: 9 September 2019 / Revised: 3 October 2019 / Accepted: 5 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Adenosine Receptors as Attractive Targets in Human Diseases )
Potent and selective adenosine receptor (AR) agonists are of pharmacological interest for the treatment of a wide range of diseases and conditions. Among these derivatives, nucleoside-based agonists represent the great majority of molecules developed and reported to date. However, the limited availability of compounds selective for a specific AR subtype (i.e., A2BAR) and a generally long and complex synthetic route for largely substituted nucleosides are the main drawbacks of this category of molecules. Non-nucleoside agonists represent an alternative set of compounds able to stimulate the AR function and based on simplified structures. This review provides an updated overview on the structural classes of non-nucleoside AR agonists and their biological activities, with emphasis on the main derivatives reported in the literature. A focus is also given to the synthetic routes employed to develop these derivatives and on molecular modeling studies simulating their interaction with ARs. View Full-Text
Keywords: purinergic receptors; adenosine receptors; adenosine receptor agonists; non-nucleoside agonists; pyridine derivatives; pyrimidine derivatives; ligand–target interaction; drug discovery purinergic receptors; adenosine receptors; adenosine receptor agonists; non-nucleoside agonists; pyridine derivatives; pyrimidine derivatives; ligand–target interaction; drug discovery
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MDPI and ACS Style

Dal Ben, D.; Lambertucci, C.; Buccioni, M.; Martí Navia, A.; Marucci, G.; Spinaci, A.; Volpini, R. Non-Nucleoside Agonists of the Adenosine Receptors: An Overview. Pharmaceuticals 2019, 12, 150.

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