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Open AccessArticle

Radioimmunotherapy in Non-Hodgkin’s Lymphoma: Retrospective Adverse Event Profiling of Zevalin and Bexxar

1
Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland
2
Molecular Health GmbH, Heidelberg 69115, Germany
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(4), 141; https://doi.org/10.3390/ph12040141
Received: 16 August 2019 / Revised: 10 September 2019 / Accepted: 17 September 2019 / Published: 20 September 2019
The development of monoclonal antibodies has dramatically changed the outcome of patients with non-Hodgkin’s lymphoma (NHL), the most common hematological malignancy. However, despite the satisfying results of monoclonal antibody treatment, only few NHL patients are permanently cured with single-agent therapies. In this context, radioimmunotherapy, the administration of radionuclides conjugated to monoclonal antibodies, is aimed to augment the single-agent efficacy of immunotherapy in order to deliver targeted radiation to tumors, particularly CD20+ B-cell lymphomas. Based on evidence from several trials in NHL, the radiolabeled antibodies 90Y-ibritumomab tiuxetan (Zevalin, Spectrum Pharmaceuticals) and 131I-tositumomab (Bexxar, GlaxoSmithKline) received FDA approval in 2002 and 2003, respectively. However, none of the two radioimmunotherapeutic agents has been broadly applied in clinical practice. The main reason for the under-utilization of radioimmunotherapy includes economic and logistic considerations. However, concerns about potential side effects have also been raised. Driven by these developments, we performed retrospective analysis of adverse events reporting Zevalin or Bexxar, extracted from the FDA’s Adverse Event Reporting System (FAERS) and the World Health Organization’s VigiBase repository. Our results indicate that the two radioimmunotherapeutic agents have both related and distinct side effect profiles and confirm their known toxicological considerations. Our work also suggests that computational analysis of real-world post-marketing data can provide informative clinical insights. While more prospective studies are necessary to fully characterize the efficacy and safety of radioimmunotherapy, we expect that it has not yet reached its full therapeutic potential in modern hematological oncology. View Full-Text
Keywords: non-Hodgkin’s lymphoma; radioimmunotherapy; 90Y-ibritumomab tiuxetan (Zevalin), 131I-tositumomab (Bexxar), FDA’s Adverse Event Reporting System (FAERS), VigiBase non-Hodgkin’s lymphoma; radioimmunotherapy; 90Y-ibritumomab tiuxetan (Zevalin), 131I-tositumomab (Bexxar), FDA’s Adverse Event Reporting System (FAERS), VigiBase
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Sachpekidis, C.; Jackson, D.B.; Soldatos, T.G. Radioimmunotherapy in Non-Hodgkin’s Lymphoma: Retrospective Adverse Event Profiling of Zevalin and Bexxar. Pharmaceuticals 2019, 12, 141.

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