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Pharmaceuticals 2019, 12(1), 37; https://doi.org/10.3390/ph12010037

Baricitinib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Janus Kinases

1
Haute Ecole Provinciale de Hainaut-Condorcet, 7330 Saint-Ghislain, Belgium
2
Formerly head of the Department of Organic Chemistry (FS), University of Mons-UMONS, 7000 Mons, Belgium
*
Author to whom correspondence should be addressed.
Received: 18 February 2019 / Revised: 5 March 2019 / Accepted: 10 March 2019 / Published: 12 March 2019
(This article belongs to the Special Issue The Story of Successful Drugs and Recent FDA-Approved Molecules)
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Abstract

In 2018, Baricitinib was approved by the Food and Drig Administration (FDA) for the treatment of rheumatoid arthritis. Baricitinib exerts its action by targeting Janus kinases (JAK). In this study, we describe the necessary steps for preparing the drug using two alternative routes. View Full-Text
Keywords: approved drugs; baricitinib; FDA; Janus kinases; protein kinase inhibitor; rheumatoid arthritis approved drugs; baricitinib; FDA; Janus kinases; protein kinase inhibitor; rheumatoid arthritis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mayence, A.; Vanden Eynde, J.J. Baricitinib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Janus Kinases. Pharmaceuticals 2019, 12, 37.

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