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Potential of the Other Genetic Information Coded by the Viral RNA Genomes as Antiviral Target

Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC); Av. del Conocimiento 17, PTS Granada, Armilla, 18016 Granada, Spain
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Pharmaceuticals 2019, 12(1), 38; https://doi.org/10.3390/ph12010038
Received: 26 February 2019 / Revised: 7 March 2019 / Accepted: 10 March 2019 / Published: 13 March 2019
In addition to the protein coding information, viral RNA genomes code functional information in structurally conserved units termed functional RNA domains. These RNA domains play essential roles in the viral cycle (e.g., replication and translation). Understanding the molecular mechanisms behind their function is essential to understanding the viral infective cycle. Further, interfering with the function of the genomic RNA domains offers a potential means of developing antiviral strategies. Aptamers are good candidates for targeting structural RNA domains. Besides its potential as therapeutics, aptamers also provide an excellent tool for investigating the functionality of RNA domains in viral genomes. This review briefly summarizes the work carried out in our laboratory aimed at the structural and functional characterization of the hepatitis C virus (HCV) genomic RNA domains. It also describes the efforts we carried out for the development of antiviral aptamers targeting specific genomic domains of the HCV and the human immunodeficiency virus type-1 (HIV-1). View Full-Text
Keywords: Viral RNA genome; Functional RNA domains; RNA–RNA interactions; Antivirals; RNA aptamers; RNA structure/function; RNA tools Viral RNA genome; Functional RNA domains; RNA–RNA interactions; Antivirals; RNA aptamers; RNA structure/function; RNA tools
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Berzal-Herranz, A.; Romero-López, C.; Berzal-Herranz, B.; Ramos-Lorente, S. Potential of the Other Genetic Information Coded by the Viral RNA Genomes as Antiviral Target. Pharmaceuticals 2019, 12, 38.

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