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Volume 12
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10.3390/ph12010034
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Article

Chemical Characterization, Antioxidant, Cytotoxic and Microbiological Activities of the Essential Oil of Leaf of Tithonia Diversifolia (Hemsl) A. Gray (Asteraceae)

by
Ana Luzia Ferreira Farias
,
Alex Bruno Lobato Rodrigues
,
Rosany Lopes Martins
,
Érica de Menezes Rabelo
,
Carlos Wagner Ferreira Farias
and
Sheylla Susan Moreira da Silva de Almeida
*
Laboratory of Pharmacognosy and Phytochemistry-Federal University of Amapá-Highway Jucelino Kubistichek, Km-02. Macapá, 68.902-280 Amapá, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(1), 34; https://doi.org/10.3390/ph12010034
Submission received: 14 January 2019 / Revised: 31 January 2019 / Accepted: 13 February 2019 / Published: 4 March 2019
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Abstract

The present study aimed to evaluate the chemical composition, antioxidant potential, and the cytotoxic and antimicrobial activity of the essential oil of the plant species Tithonia diversifolia (Hemsl) A. Gray. The essential oil obtained was used to identify the chemical compounds present through the techniques of GC-MS and NMR. The antioxidant potential was calculated by the sequestration method of 2,2-diphenyl-1-picrylhydrazyl. For cytotoxic activity, the larval mortality of Artemia salina was evaluated. The main chemical constituents identified are αpinene (9.9%), Limonene (5.40%), (Z)-β-ocimene (4.02%), p-cymen-8-ol (3.0%), Piperitone (11.72%), (E)-nerolidol (3.78%) and Spathulenol (10.8%). In the evaluation of the antimicrobial activity, bacterial strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were used. The results showed that the bacterium E. coli were more susceptible to the presence of the essential oil, presenting minimal inhibitory concentration at the concentrations that were exposed. The essential oil presented antioxidant activity of 54.6% at the concentration of 5 mg·mL−1 and provided a CI50 of 4.30. It was observed that the essential oil of this species was highly toxic against A. salina lavas, as its cytotoxic activity showed an LC50 of 3.11. Thus, it is concluded that T. diversifolia oils are effective in inhibiting bacterial growth and reducing oxidative stress.
Keywords: secondary metabolites; margaridão; medicinal plants secondary metabolites; margaridão; medicinal plants
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MDPI and ACS Style

Ferreira Farias, A.L.; Lobato Rodrigues, A.B.; Lopes Martins, R.; de Menezes Rabelo, É.; Ferreira Farias, C.W.; Moreira da Silva de Almeida, S.S. Chemical Characterization, Antioxidant, Cytotoxic and Microbiological Activities of the Essential Oil of Leaf of Tithonia Diversifolia (Hemsl) A. Gray (Asteraceae). Pharmaceuticals 2019, 12, 34. https://doi.org/10.3390/ph12010034

AMA Style

Ferreira Farias AL, Lobato Rodrigues AB, Lopes Martins R, de Menezes Rabelo É, Ferreira Farias CW, Moreira da Silva de Almeida SS. Chemical Characterization, Antioxidant, Cytotoxic and Microbiological Activities of the Essential Oil of Leaf of Tithonia Diversifolia (Hemsl) A. Gray (Asteraceae). Pharmaceuticals. 2019; 12(1):34. https://doi.org/10.3390/ph12010034

Chicago/Turabian Style

Ferreira Farias, Ana Luzia, Alex Bruno Lobato Rodrigues, Rosany Lopes Martins, Érica de Menezes Rabelo, Carlos Wagner Ferreira Farias, and Sheylla Susan Moreira da Silva de Almeida. 2019. "Chemical Characterization, Antioxidant, Cytotoxic and Microbiological Activities of the Essential Oil of Leaf of Tithonia Diversifolia (Hemsl) A. Gray (Asteraceae)" Pharmaceuticals 12, no. 1: 34. https://doi.org/10.3390/ph12010034

APA Style

Ferreira Farias, A. L., Lobato Rodrigues, A. B., Lopes Martins, R., de Menezes Rabelo, É., Ferreira Farias, C. W., & Moreira da Silva de Almeida, S. S. (2019). Chemical Characterization, Antioxidant, Cytotoxic and Microbiological Activities of the Essential Oil of Leaf of Tithonia Diversifolia (Hemsl) A. Gray (Asteraceae). Pharmaceuticals, 12(1), 34. https://doi.org/10.3390/ph12010034

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