The Role of NCOA4-Mediated Ferritinophagy in Health and Disease
Abstract
:1. Introduction
2. NCOA4 Mediates Ferritin Transport to the Lysosome for Degradation
3. NCOA4 Mediates Ferritin Iron Release to Support Erythropoiesis
4. NCOA4-Mediated Ferritinophagy Modulates Ferroptosis
5. Ferritinophagy and Ferroptosis in Disease
5.1. Neurodegenerative Disease
5.2. Cancer
5.3. Infectious Disease
6. Conclusions and Future Directions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
NCOA4 | Nuclear Receptor Co-Activator 4 |
ATP | Adenosine Triphosphate |
DNA | Deoxyribonucleic acid |
ROS | Reactive Oxygen Species |
TfR | Transferrin Receptor |
DMT1 | Divalent Metal Transporter 1 |
FPN | Ferroportin |
FTH1 | Ferritin Heavy Chain 1 |
FTL | Ferritin Light chain |
Fe | Iron |
PI3P | Phosphatidylinositol-3-phosphate |
MEFs | Mouse Embryonic Fibroblasts |
Atg7 | Autophagy-related protein 7 |
SILAC | Stable Isotope Labeling by Amino-acids in Cell culture |
LC-MS | Liquid Chromatography-Mass Spectrometry |
HERC2 | HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2 |
NEURL4 | Neuralized E3 Ubiquitin Protein Ligase 4 |
PCBP1 | Poly rC–binding protein 1 |
LIR motif | LC3-interaction region |
ESCRT | Endosomal Sorting Complex Required for Transport |
CNS | Central Nervous System |
AR | Androgen Receptor |
RBC | Red Blood Cell |
GPx4 | Glutathione Peroxidase 4 |
RSL3 | RAS-selective lethal 3 |
BSO | Buthionine Sulfoximine |
DFO | Deferoxamine |
SOD | Superoxide Dismutase |
IREB2 | Iron Response Element Binding Protein 2 |
ND | Neurodegenerative Disease |
PD | Parkinson’s Disease |
AD | Alzheimer’s Disease |
NBIA | Neurodegeneration with Brain Iron Accumulation |
HCMV | Human Cytomegalovirus |
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Santana-Codina, N.; Mancias, J.D. The Role of NCOA4-Mediated Ferritinophagy in Health and Disease. Pharmaceuticals 2018, 11, 114. https://doi.org/10.3390/ph11040114
Santana-Codina N, Mancias JD. The Role of NCOA4-Mediated Ferritinophagy in Health and Disease. Pharmaceuticals. 2018; 11(4):114. https://doi.org/10.3390/ph11040114
Chicago/Turabian StyleSantana-Codina, Naiara, and Joseph D. Mancias. 2018. "The Role of NCOA4-Mediated Ferritinophagy in Health and Disease" Pharmaceuticals 11, no. 4: 114. https://doi.org/10.3390/ph11040114