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Open AccessArticle

Nanocomposite Based on Poly (para-phenylene)/Chemical Reduced Graphene Oxide as a Platform for Simultaneous Detection of Ascorbic Acid, Dopamine and Uric Acid

1
Université Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Equipe de Chimie Biorganique et Bioinorganique (ECBB), Bât 420, 2 Rue du Doyen Georges Poitou, 91400 Orsay, France
2
Laboratory of Interfaces and Advanced Materials, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(5), 1256; https://doi.org/10.3390/s20051256
Received: 1 February 2020 / Revised: 11 February 2020 / Accepted: 18 February 2020 / Published: 25 February 2020
(This article belongs to the Special Issue Sensors for Environmental and Life Science Applications)
In this study, an efficient and simple designed nanohybrid created for individual and simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). This nanohybrid is a combination of chemical reduced graphene oxide (CRGO) and redox poly(para-phenylene) (Fc-ac-PP) modified in a lateral position with ferrrocenyl group CRGO/Fc-ac-PPP. The CRGO/Fc-ac-PPP nanohybrid demonstrated a synergistic effect resulting in a large conductivity, surface area and catalytic properties provided by the redox attached ferrocene. Moreover, this nanocomposite is able to detect individually as well as simultaneously AA, DA and UA in a co-existence system with defined and separated redox peaks oxidation. The linear response ranges for AA, DA and UA, when detected simultaneously, are 0.1–10000 μM, 0.0001–1000 μM and 0.1–10000 μM, respectively, and the detection limits (S/N = 3) are 0.046 μM, 0.2 nM and 0.013 μM, respectively. The proposed sensor shown satisfactory results when applied to real spiked urine samples for measuring the abnormal high or lowconcentration of AA, DA and UA in vivo. View Full-Text
Keywords: nanocomposite; reduced graphene oxide; poly(paraphenylene); ascorbic acid; dopamine; uric acid; urine nanocomposite; reduced graphene oxide; poly(paraphenylene); ascorbic acid; dopamine; uric acid; urine
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MDPI and ACS Style

Hsine, Z.; Bizid, S.; Mlika, R.; Sauriat-Dorizon, H.; Haj Said, A.; Korri-Youssoufi, H. Nanocomposite Based on Poly (para-phenylene)/Chemical Reduced Graphene Oxide as a Platform for Simultaneous Detection of Ascorbic Acid, Dopamine and Uric Acid. Sensors 2020, 20, 1256.

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