Next Article in Journal
An Experimental Strategy for Characterizing Inductive Electromagnetic Energy Harvesters
Previous Article in Journal
Absolute Positioning and Orientation of MLSS in a Subway Tunnel Based on Sparse Point-Assisted DR
Review

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

by 1,2,*,† and 1,3,†
1
School of Chemical and Materials Engineering, National University of Sciences & Technology, H-12, Islamabad 44000, Pakistan
2
School of Materials Sciences & Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore
3
Pak-Austria Fachhochshule, Institute of Applied Sciences & Technology, Khanpur Road, Mang, Haripur 22650, Pakistan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2020, 20(3), 646; https://doi.org/10.3390/s20030646
Received: 11 November 2019 / Revised: 6 December 2019 / Accepted: 18 December 2019 / Published: 23 January 2020
(This article belongs to the Section Biosensors)
Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications. View Full-Text
Keywords: interleukin 6; biosensor; cancer detection; electrochemical sensor; optical sensor interleukin 6; biosensor; cancer detection; electrochemical sensor; optical sensor
Show Figures

Figure 1

MDPI and ACS Style

Khan, M.A.; Mujahid, M. Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6. Sensors 2020, 20, 646. https://doi.org/10.3390/s20030646

AMA Style

Khan MA, Mujahid M. Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6. Sensors. 2020; 20(3):646. https://doi.org/10.3390/s20030646

Chicago/Turabian Style

Khan, Munezza A., and Mohammad Mujahid. 2020. "Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6" Sensors 20, no. 3: 646. https://doi.org/10.3390/s20030646

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop