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Open AccessArticle

SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement

1
Institute of Technical Chemistry, Leibniz University of Hannover, 30167 Hannover, Germany
2
School of Engineering and the Built Environment, Edinburgh Napier University, Edinburgh EH10 5DT, UK
3
Cluster of Excellence PhoenixD (Photonics, Optics, and Engineering—Innovation Across Disciplines), 30167 Hannover, Germany
4
Hannover Centre for Optical Technologies, Leibniz University of Hannover, 30167 Hannover, Germany
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(10), 2889; https://doi.org/10.3390/s20102889
Received: 20 April 2020 / Revised: 11 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
(This article belongs to the Special Issue Integrated Photonics for Novel Sensing and Measurement Applications)
We present a surface plasmon resonance (SPR) biosensor that is based on a planar-optical multi-mode (MM) polymer waveguide structure applied for the detection of biomolecules in the lower nano-molar (nM) range. The basic sensor shows a sensitivity of 608.6 nm/RIU when exposed to refractive index changes with a measurement resolution of 4.3 × 10−3 RIU. By combining the SPR sensor with an aptamer-functionalized, gold-nanoparticle (AuNP)-enhanced sandwich assay, the detection of C-reactive protein (CRP) in a buffer solution was achieved with a response of 0.118 nm/nM. Due to the multi-mode polymer waveguide structure and the simple concept, the reported biosensor is well suited for low-cost disposable lab-on-a-chip applications and can be used with rather simple and economic devices. In particular, the sensor offers the potential for fast and multiplexed detection of several biomarkers on a single integrated platform. View Full-Text
Keywords: surface plasmon resonance (SPR); sensor; planar-optical; multi-mode; waveguide; biosensor; aptamer; gold-nanoparticle; lab-on-a-chip surface plasmon resonance (SPR); sensor; planar-optical; multi-mode; waveguide; biosensor; aptamer; gold-nanoparticle; lab-on-a-chip
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MDPI and ACS Style

Walter, J.-G.; Eilers, A.; Alwis, L.S.M.; Roth, B.W.; Bremer, K. SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement. Sensors 2020, 20, 2889.

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