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Characterization and Relaxation Properties of a Series of Monodispersed Magnetic Nanoparticles

Ferrogels Ultrasonography for Biomedical Applications

Ural State Medical University, 620028 Ekaterinburg, Russia
Institute of Natural Sciences and Mathematics Ural Federal University, 620002 Ekaterinburg, Russia
Institute of Electrophysics, Ural Division RAS, 620016 Ekaterinburg, Russia
M.N. Mikheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia
Departamento de Electricidad y Electrónica and BCMaterials, Universidad del País Vasco UPV/EHU, 48080 Bilbao, Spain
Author to whom correspondence should be addressed.
Sensors 2019, 19(18), 3959;
Received: 16 July 2019 / Revised: 2 September 2019 / Accepted: 10 September 2019 / Published: 13 September 2019
(This article belongs to the Special Issue Biosensors with Magnetic Nanocomponents)
Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG samples were prepared in various shapes that are suitable for different characterization techniques. Thin cylindrical samples were used to simulate the case of targeted drug delivery test through blood vessels. Samples of larger size that were in the shape of cylindrical plates were used for the evaluation of the FG applicability as substitutes for damaged structures, such as bone or cartilage tissues. Regardless of the shape of the samples and the conditions of their location, the boundaries of FG were confidently visualized over the entire range of concentrations of MNPs while using medical ultrasound. The amplitude of the reflected echo signal was higher for the higher concentration of MNPs in the gel. This result was not related to the influence of the MNPs on the intensity of the reflected echo signal directly, since the wavelength of the ultrasonic effect used is much larger than the particle size. Qualitative theoretical model for the understanding of the experimental results was proposed while taking into account the concept that at the acoustic oscillations of the hydrogel, the macromolecular net, and water in the gel porous structure experience the viscous Stocks-like interaction. View Full-Text
Keywords: magnetic nanoparticles; ferrogels; medical ultrasound; sonography; biomedical applications magnetic nanoparticles; ferrogels; medical ultrasound; sonography; biomedical applications
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MDPI and ACS Style

Blyakhman, F.A.; Sokolov, S.Y.; Safronov, A.P.; Dinislamova, O.A.; Shklyar, T.F.; Zubarev, A.Y.; Kurlyandskaya, G.V. Ferrogels Ultrasonography for Biomedical Applications. Sensors 2019, 19, 3959.

AMA Style

Blyakhman FA, Sokolov SY, Safronov AP, Dinislamova OA, Shklyar TF, Zubarev AY, Kurlyandskaya GV. Ferrogels Ultrasonography for Biomedical Applications. Sensors. 2019; 19(18):3959.

Chicago/Turabian Style

Blyakhman, Felix A., Sergey Yu Sokolov, Alexander P. Safronov, Olga A. Dinislamova, Tatyana F. Shklyar, Andrey Yu Zubarev, and Galina V. Kurlyandskaya. 2019. "Ferrogels Ultrasonography for Biomedical Applications" Sensors 19, no. 18: 3959.

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