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Open AccessArticle

A Smart Tongue Depressor-Based Biosensor for Glucose

College of Engineering, Peking University, Beijing 100871, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2019, 19(18), 3864;
Received: 13 June 2019 / Revised: 25 July 2019 / Accepted: 12 August 2019 / Published: 11 September 2019
(This article belongs to the Section Biosensors)
The development of new bioelectronic platforms for direct interactions with oral fluid could open up significant opportunities for healthcare monitoring. A tongue depressor is a widely used medical tool that is inserted into the mouth, where it comes into close contact with saliva. Glucose is a typical salivary biomarker. Herein, we report—for the first time—a tongue depressor-based biosensor for the detection of glucose in both phosphate buffer and real human saliva. Carbon nanotubes (CNTs) are attractive electronic materials, with excellent electrochemical properties. The sensor is constructed by printing CNTs and silver/silver chloride (Ag/AgCl) to form three electrodes in an electrochemical cell: Working, reference, and counter electrodes. The enzyme glucose oxidase (GOD) is immobilized on the working electrode. The glucose detection performance of the sensor is excellent, with a detection range of 7.3 μM to 6 mM. The glucose detection time is about 3 min. The discretion between healthy people’s and simulated diabetic patients’ salivary samples is clear and easy to tell. We anticipate that the biosensor could open up new opportunities for the monitoring of salivary biomarkers and advance healthcare applications. View Full-Text
Keywords: tongue depressor; biosensor; salivary glucose; carbon nanotube; enzyme; hydrogen peroxide tongue depressor; biosensor; salivary glucose; carbon nanotube; enzyme; hydrogen peroxide
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MDPI and ACS Style

Luo, X.; Shi, W.; Liu, Y.; Sha, P.; Chu, Y.; Cui, Y. A Smart Tongue Depressor-Based Biosensor for Glucose. Sensors 2019, 19, 3864.

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