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Sensors 2015, 15(12), 31987-31998;

Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins

Department of Chemistry, University of Delhi, Delhi 110007, India
Center for Advanced Materials, University of Massachusetts Lowell, Lowell, MA 01854, USA
Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
Authors to whom correspondence should be addressed.
Academic Editor: Ki-Hyun Kim
Received: 26 September 2015 / Revised: 5 December 2015 / Accepted: 10 December 2015 / Published: 19 December 2015
(This article belongs to the Special Issue The Use of New and/or Improved Materials for Sensing Applications)
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We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investigated by their cellular uptake in HeLa cells by TP confocal microscopy. View Full-Text
Keywords: 3-(4-diethylaminocinnamoyl) coumarins; fluorescence; DCP; nerve gas sensors; two-photon fluorescence 3-(4-diethylaminocinnamoyl) coumarins; fluorescence; DCP; nerve gas sensors; two-photon fluorescence

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Yadav, P.; Gill, H.S.; Chand, K.; Li, L.; Kumar, J.; Sharma, S.K. Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins. Sensors 2015, 15, 31987-31998.

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