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Sensors 2015, 15(10), 25313-25335;

A Low Noise Amplifier for Neural Spike Recording Interfaces

Institute of Microelectronics of Seville, Avda. Americo Vespucio s/n, Sevilla 41092, Spain
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 24 July 2015 / Revised: 12 September 2015 / Accepted: 21 September 2015 / Published: 30 September 2015
(This article belongs to the Section Biosensors)
PDF [783 KB, uploaded 12 October 2015]


This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 μVrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz–7.4 kHz and consumes 1.92 μW. The performance of the proposed LNA has been validated through in vivo experiments with animal models. View Full-Text
Keywords: Low-Noise Amplifier; neural spike recording; biomedical circuit; circuit sizing Low-Noise Amplifier; neural spike recording; biomedical circuit; circuit sizing

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ruiz-Amaya, J.; Rodriguez-Perez, A.; Delgado-Restituto, M. A Low Noise Amplifier for Neural Spike Recording Interfaces. Sensors 2015, 15, 25313-25335.

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