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Article

An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation

by
Yung-Sheng Lin
1,2,
Chih-Hui Yang
1,
Chih-Yu Wang
3,
Fang-Rong Chang
4,
Keng-Shiang Huang
5,* and
Wan-Chen Hsieh
1
1
Department of Biological Science & Technology, I-Shou University, Kaohsiung 84001, Taiwan
2
Department of Applied Cosmetology and Master Program of Cosmetic Science, Hung-Kuang University, Taichung 43302, Taiwan
3
Department of Biomedical Engineering, I-Shou University, Kaohsiung 82445, Taiwan
4
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan
*
Author to whom correspondence should be addressed.
Sensors 2012, 12(2), 1455-1467; https://doi.org/10.3390/s120201455
Submission received: 30 December 2011 / Revised: 19 January 2012 / Accepted: 31 January 2012 / Published: 1 February 2012
(This article belongs to the Special Issue Biochips)
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Abstract

This study presents the development of a robust aluminum-based microfluidic chip fabricated by conventional mechanical micromachining (computer numerical control-based micro-milling process). It applied the aluminum-based microfluidic chip to form poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating CdSe/ZnS quantum dots (QDs). A cross-flow design and flow-focusing system were employed to control the oil-in-water (o/w) emulsification to ensure the generation of uniformly-sized droplets. The size of the droplets could be tuned by adjusting the flow rates of the water and oil phases. The proposed microfluidic platform is easy to fabricate, set up, organize as well as program, and is valuable for further applications under harsh reaction conditions (high temperature and/or strong organic solvent systems). The proposed method has the advantages of actively controlling the droplet diameter, with a narrow size distribution, good sphericity, as well as being a simple process with a high throughput. In addition to the fluorescent PLGA microparticles in this study, this approach can also be applied to many applications in the pharmaceutical and biomedical area.
Keywords: microfluidic emulsification; poly(lactic-co-glycolic acid) (PLGA); quantum dots (QDs); microsphere microfluidic emulsification; poly(lactic-co-glycolic acid) (PLGA); quantum dots (QDs); microsphere

Share and Cite

MDPI and ACS Style

Lin, Y.-S.; Yang, C.-H.; Wang, C.-Y.; Chang, F.-R.; Huang, K.-S.; Hsieh, W.-C. An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation. Sensors 2012, 12, 1455-1467. https://doi.org/10.3390/s120201455

AMA Style

Lin Y-S, Yang C-H, Wang C-Y, Chang F-R, Huang K-S, Hsieh W-C. An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation. Sensors. 2012; 12(2):1455-1467. https://doi.org/10.3390/s120201455

Chicago/Turabian Style

Lin, Yung-Sheng, Chih-Hui Yang, Chih-Yu Wang, Fang-Rong Chang, Keng-Shiang Huang, and Wan-Chen Hsieh. 2012. "An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation" Sensors 12, no. 2: 1455-1467. https://doi.org/10.3390/s120201455

APA Style

Lin, Y.-S., Yang, C.-H., Wang, C.-Y., Chang, F.-R., Huang, K.-S., & Hsieh, W.-C. (2012). An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation. Sensors, 12(2), 1455-1467. https://doi.org/10.3390/s120201455

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