[4-(3,4-Dimethoxyphenyl)-3,6-dimethyl-2-phenyl-3,4-dihydroquinolin-1(2H)-yl)](furan-2-yl)methanone

Round 1

Reviewer 1 Report

The authors present the synthesis of one new compound. The title compound is fully characterized, including X-ray structure, which confirmed the original hypothesis. I suggest accepting it in its present form.

Author Response

Please check the file.

Author Response File: Author Response.pdf

Reviewer 2 Report

The authors report a multicomponent synthesis of a tetrahydroquinoline following a known highly diastereoselective Povarov protocol, starting from p-toluidine, benzaldehyde and trans-methyl-isoeugenol. A new additional step consists of a N-furoylation reaction.

The work is clearly presented and the experimental procedures are carefully detailed and the conclusions are reasonably supported by the data. The characterization of the substrates is exhaustive, including an x-Ray structure, so nothing to object with that fine work.

There are however some minor issues to be addressed:

Line 47: “However, the examples regarding the synthesis and characterization of…”

N-(tetrahydroquinolin-1-yl), N-Acyl and so on… N should be formatted in italics.

Overall, I think they authors provide a nice contribution to the synthesis of tetrahydroquinolines that will be of interest for medicinal and organic chemists and, consequently I support the publication of the manuscript in MolBank after the comments above have been taken into account.

I suggest a revision of the redaction. Although I am not a native English, the style sounds childish to me. In addition there are some huge sentences in the characterization section that could be split into two or three sentences.

Author Response

please, check the file.

Author Response File: Author Response.pdf