Next Article in Journal
A Direct Method for the Efficient Synthesis of Hydroxyalkyl-Containing Azoxybenzenes
Previous Article in Journal
2,3,5-Tri-O-benzyl-d-xylofuranose
Short Note

2-(4-Chlorophenyl)-4-(3,4-dimethoxy-phenyl)-6-methoxy-3-methylquinoline

Laboratorio de Química Orgánica y Biomolecular, CMN, Parque Tecnológico Guatiguará, Km 2 vía Refugio, Universidad Industrial de Santander, Piedecuesta A.A. 681011, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Ge Meng
Molbank 2022, 2022(2), M1383; https://doi.org/10.3390/M1383
Received: 22 May 2022 / Revised: 10 June 2022 / Accepted: 10 June 2022 / Published: 13 June 2022
A 2,4-diarylquinoline derivative, 2-(4-chlorophenyl)-4-(3,4-dimethoxyphenyl)-6-methoxy-3-methylquinoline, was synthesized in a conventional two-step procedure from p-anisidine, p-chlorobenzaldehyde and methyl isoeugenol as available starting reagents through a sequence of BF3·OEt2-catalyzed Povarov cycloaddition reaction/oxidative dehydrogenation aromatization processes under microwave irradiation conditions in the presence of a green oxidative I2-DMSO system. The structure of the compound was fully characterized by FT-IR, 1H and 13C-NMR, ESI-MS, and elemental analysis. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the Molinspiration Cheminformatics software. The diarylquinoline molecule obtained is an interesting model with increased lipophilicity and thus permeability, an important descriptor for quinoline-based drug design. Such types of derivatives are known for their anticancer, antitubercular, antifungal, and antiviral activities. View Full-Text
Keywords: 2,4-diarylquinoline; methyl isoeugenol; Povarov reaction; oxidative dehydrogenation aromatization process; Lipinski’s descriptors 2,4-diarylquinoline; methyl isoeugenol; Povarov reaction; oxidative dehydrogenation aromatization process; Lipinski’s descriptors
Show Figures

Graphical abstract

MDPI and ACS Style

Rodríguez Enciso, D.A.; Puerto Galvis, C.E.; Kouznetsov, V.V. 2-(4-Chlorophenyl)-4-(3,4-dimethoxy-phenyl)-6-methoxy-3-methylquinoline. Molbank 2022, 2022, M1383. https://doi.org/10.3390/M1383

AMA Style

Rodríguez Enciso DA, Puerto Galvis CE, Kouznetsov VV. 2-(4-Chlorophenyl)-4-(3,4-dimethoxy-phenyl)-6-methoxy-3-methylquinoline. Molbank. 2022; 2022(2):M1383. https://doi.org/10.3390/M1383

Chicago/Turabian Style

Rodríguez Enciso, Duván A., Carlos E. Puerto Galvis, and Vladimir V. Kouznetsov. 2022. "2-(4-Chlorophenyl)-4-(3,4-dimethoxy-phenyl)-6-methoxy-3-methylquinoline" Molbank 2022, no. 2: M1383. https://doi.org/10.3390/M1383

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop