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(E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one

Mathematics, Natural, and Health Sciences Division, University of Hawai‘i West O‘ahu, 91-1001 Farrington Hwy, Kapolei, HI 96707, USA
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Author to whom correspondence should be addressed.
Academic Editor: Oleg A. Rakitin
Molbank 2021, 2021(3), M1269; https://doi.org/10.3390/M1269
Received: 29 April 2021 / Revised: 22 July 2021 / Accepted: 27 July 2021 / Published: 10 August 2021
(This article belongs to the Section Organic Synthesis)
Imidazole-containing chalcones have been shown to be strongly effective against Aspergillusfumigatus, the causative agent for the disease pulmonary aspergillosis. Claisen–Schmidt condensation of 4-(1H-imidazol-1-yl)benzaldehyde with 4′-methylacetophenone using aqueous sodium hydroxide in methanol yielded the novel compound (E)-3-[4-(1H-imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one in good yield and purity after recrystallization from hot methanol. With the known antifungal properties of these combined pharmacophores, this novel compound is suitable for anti-aspergillus activity study. View Full-Text
Keywords: chalcone; synthesis; aldol; pulmonary aspergillosis; imidazole chalcone; synthesis; aldol; pulmonary aspergillosis; imidazole
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MDPI and ACS Style

Bailey, N.; Ashburn, B.O. (E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one. Molbank 2021, 2021, M1269. https://doi.org/10.3390/M1269

AMA Style

Bailey N, Ashburn BO. (E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one. Molbank. 2021; 2021(3):M1269. https://doi.org/10.3390/M1269

Chicago/Turabian Style

Bailey, Nicholas, and Bradley O. Ashburn 2021. "(E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one" Molbank 2021, no. 3: M1269. https://doi.org/10.3390/M1269

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