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Short Note

4-Amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one

1
Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Dimitrios Matiadis and Eleftherios Halevas
Molbank 2021, 2021(2), M1237; https://doi.org/10.3390/M1237
Received: 30 May 2021 / Revised: 10 June 2021 / Accepted: 11 June 2021 / Published: 15 June 2021
The new 4-amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one was successfully prepared through the Au/TiO2-catalyzed NaBH4 activation and chemoselective reduction of the new 4-nitro-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one. The latter was synthesized by the one-pot tandem reactions of 6-hydroxy-5,7-dinitrocoumarin with p-tolylmethanol under Au/TiO2 catalysis. The dinitrocoumarin was obtained by the nitration of 6-hydroxycoumarin with cerium ammonium nitrate (CAN). The structure of the synthesized compounds was confirmed by FT-IR, HR-MS, 1H-NMR and 13C-NMR analysis. Preliminary biological tests show low anti-lipid peroxidation activity for the title compound. View Full-Text
Keywords: Au-nanoparticles; NaBH4; amino-substituted fused oxazolocoumarin; fused oxazolocoumarins; chemoselective reduction; o-hydroxynitrocoumarins Au-nanoparticles; NaBH4; amino-substituted fused oxazolocoumarin; fused oxazolocoumarins; chemoselective reduction; o-hydroxynitrocoumarins
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MDPI and ACS Style

Vlachou, E.-E.N.; Balalas, T.D.; Hadjipavlou-Litina, D.J.; Litinas, K.E. 4-Amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one. Molbank 2021, 2021, M1237. https://doi.org/10.3390/M1237

AMA Style

Vlachou E-EN, Balalas TD, Hadjipavlou-Litina DJ, Litinas KE. 4-Amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one. Molbank. 2021; 2021(2):M1237. https://doi.org/10.3390/M1237

Chicago/Turabian Style

Vlachou, Evangelia-Eirini N., Thomas D. Balalas, Dimitra J. Hadjipavlou-Litina, and Konstantinos E. Litinas 2021. "4-Amino-2-(p-tolyl)-7H-chromeno[5,6-d]oxazol-7-one" Molbank 2021, no. 2: M1237. https://doi.org/10.3390/M1237

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