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Communication

Synthesis of 4-[(1H-Benzimidazol-2-yl)sulfanyl]benzaldehyde and 2-({4-[(1H-Benzimidazol-2-yl)sulfanyl]phenyl}methylidene)hydrazine-1-carbothioamide

Chemistry Department, Faculty of Arts and Science, Northern Border University, P.O. Box 840, Rafha 91911, Saudi Arabia
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Authors to whom correspondence should be addressed.
Academic Editors: Dimitrios Matiadis and Eleftherios Halevas
Molbank 2021, 2021(3), M1273; https://doi.org/10.3390/M1273
Received: 27 July 2021 / Revised: 15 August 2021 / Accepted: 18 August 2021 / Published: 26 August 2021
Here we describe the preparation of 2-(4-((1H-benzo[d]imidazol-2-yl)thio)-benzylidene)-hydrazine-1-carbothioamide in two steps. In the first step, 1,3-dihydro-2H-1,3-benzimidazole-2-thione was reacted with 4-fluorobenzaldehyde in DMSO to get 4-[(1H-benzimidazol-2-yl)sulfanyl]benzaldehyde in high yield. The reaction of the obtained aldehyde with thiosemicarbazide in ethanol at reflux temperature yielded 2-({4-[(1H-benzimidazol-2-yl)sulfanyl]phenyl}methylidene)hydrazine-1-carbothioamide. The structure of the synthesized compounds was established by NMR spectroscopy (1H, 13C), mass spectrometry, and infrared spectroscopy. View Full-Text
Keywords: benzimidazole; nucleophilic aromatic substitution; thiosemicarbazone benzimidazole; nucleophilic aromatic substitution; thiosemicarbazone
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MDPI and ACS Style

Ubeid, M.T.; Thabet, H.K.; Abu Shuheil, M.Y. Synthesis of 4-[(1H-Benzimidazol-2-yl)sulfanyl]benzaldehyde and 2-({4-[(1H-Benzimidazol-2-yl)sulfanyl]phenyl}methylidene)hydrazine-1-carbothioamide. Molbank 2021, 2021, M1273. https://doi.org/10.3390/M1273

AMA Style

Ubeid MT, Thabet HK, Abu Shuheil MY. Synthesis of 4-[(1H-Benzimidazol-2-yl)sulfanyl]benzaldehyde and 2-({4-[(1H-Benzimidazol-2-yl)sulfanyl]phenyl}methylidene)hydrazine-1-carbothioamide. Molbank. 2021; 2021(3):M1273. https://doi.org/10.3390/M1273

Chicago/Turabian Style

Ubeid, Mustafa T., Hamdy K. Thabet, and Mohamed Y. Abu Shuheil 2021. "Synthesis of 4-[(1H-Benzimidazol-2-yl)sulfanyl]benzaldehyde and 2-({4-[(1H-Benzimidazol-2-yl)sulfanyl]phenyl}methylidene)hydrazine-1-carbothioamide" Molbank 2021, no. 3: M1273. https://doi.org/10.3390/M1273

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