Next Article in Journal
Previous Article in Journal
Open AccessCommunication

(S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate

Department of Pharmacy - Pharmaceutical Sciences, University of Bari, Via E. Orabona 4, 70126 Bari, Italy
Authors to whom correspondence should be addressed.
Molbank 2019, 2019(1), M1049;
Received: 18 January 2019 / Revised: 15 February 2019 / Accepted: 18 February 2019 / Published: 21 February 2019
(This article belongs to the Section Organic Synthesis)
A multistep gram-scale synthesis of (S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate (2) has been developed. The title compound was prepared starting from commercially available l-DOPA which was O- and N-protected before undergoing iodination by CF3CO2Ag/I2. The structure of the target compound was confirmed using IR, 1H-NMR, 13C-NMR, 2D (COSY, HSQC) NMR spectroscopy, as well as ESI-MS and HRMS. View Full-Text
Keywords: phenylalanine; l-DOPA; iodination; medicinal chemistry phenylalanine; l-DOPA; iodination; medicinal chemistry
Show Figures

Graphical abstract

MDPI and ACS Style

Lentini, G.; Cavalluzzi, M.M.; Degennaro, L.; Fracchiolla, G.; Perna, F.; Scilimati, A. (S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate. Molbank 2019, 2019, M1049.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop