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Open AccessCommunication

(S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate

Department of Pharmacy - Pharmaceutical Sciences, University of Bari, Via E. Orabona 4, 70126 Bari, Italy
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Molbank 2019, 2019(1), M1049; https://doi.org/10.3390/M1049
Received: 18 January 2019 / Revised: 15 February 2019 / Accepted: 18 February 2019 / Published: 21 February 2019
(This article belongs to the Section Organic Synthesis)
A multistep gram-scale synthesis of (S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate (2) has been developed. The title compound was prepared starting from commercially available l-DOPA which was O- and N-protected before undergoing iodination by CF3CO2Ag/I2. The structure of the target compound was confirmed using IR, 1H-NMR, 13C-NMR, 2D (COSY, HSQC) NMR spectroscopy, as well as ESI-MS and HRMS. View Full-Text
Keywords: phenylalanine; l-DOPA; iodination; medicinal chemistry phenylalanine; l-DOPA; iodination; medicinal chemistry
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MDPI and ACS Style

Lentini, G.; Cavalluzzi, M.M.; Degennaro, L.; Fracchiolla, G.; Perna, F.; Scilimati, A. (S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate. Molbank 2019, 2019, M1049.

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