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Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universi-tät Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany
Chemistry Department, Faculty of Science, Menofia University, Gamal Abdel-Nasser Street, 32511 Shebin El-Koum, Menofia, Egypt
Department of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany
Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany
Author to whom correspondence should be addressed.
Molbank 2019, 2019(1), M1048;
Received: 22 December 2018 / Revised: 8 February 2019 / Accepted: 12 February 2019 / Published: 20 February 2019
(This article belongs to the Section Structure Determination)
The title compound N1-{4-[2-(methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine (2) was synthesized via nucleophilic aromatic substitution of 2-chloro-4-[2-(methylthio)-1H-imidazol-5-yl]pyridine (3) and p-phenylenediamine under acidic conditions. The synthesized compound 2 was characterized by 1H-NMR, 13C-NMR, MS HPLC, IR and UV-VIS. Additionally, the structure of 2 was confirmed by single crystal X-ray diffraction. Pyridinylimidazole 2 displays moderate affinity towards the c-Jun N-terminal kinase 3 and shows selectivity versus the closely related p38α mitogen-activated protein kinase. View Full-Text
Keywords: pyridinylimidazole; kinase inhibitor; c-Jun N-terminal kinase 3; JNK3; heterocycle; single crystal diffraction pyridinylimidazole; kinase inhibitor; c-Jun N-terminal kinase 3; JNK3; heterocycle; single crystal diffraction
MDPI and ACS Style

El-Gokha, A.; Ansideri, F.; Andreev, S.; Schollmeyer, D.; Laufer, S.; Koch, P. N1-{4-[2-(Methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine. Molbank 2019, 2019, M1048.

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