Next Article in Journal
(S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate
Previous Article in Journal
4-(4-Chlorophenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione
Open AccessFeature PaperShort Note

N1-{4-[2-(Methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine

1
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universi-tät Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany
2
Chemistry Department, Faculty of Science, Menofia University, Gamal Abdel-Nasser Street, 32511 Shebin El-Koum, Menofia, Egypt
3
Department of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany
4
Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(1), M1048; https://doi.org/10.3390/M1048
Received: 22 December 2018 / Revised: 8 February 2019 / Accepted: 12 February 2019 / Published: 20 February 2019
(This article belongs to the Section Structure Determination)
The title compound N1-{4-[2-(methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine (2) was synthesized via nucleophilic aromatic substitution of 2-chloro-4-[2-(methylthio)-1H-imidazol-5-yl]pyridine (3) and p-phenylenediamine under acidic conditions. The synthesized compound 2 was characterized by 1H-NMR, 13C-NMR, MS HPLC, IR and UV-VIS. Additionally, the structure of 2 was confirmed by single crystal X-ray diffraction. Pyridinylimidazole 2 displays moderate affinity towards the c-Jun N-terminal kinase 3 and shows selectivity versus the closely related p38α mitogen-activated protein kinase. View Full-Text
Keywords: pyridinylimidazole; kinase inhibitor; c-Jun N-terminal kinase 3; JNK3; heterocycle; single crystal diffraction pyridinylimidazole; kinase inhibitor; c-Jun N-terminal kinase 3; JNK3; heterocycle; single crystal diffraction
MDPI and ACS Style

El-Gokha, A.; Ansideri, F.; Andreev, S.; Schollmeyer, D.; Laufer, S.; Koch, P. N1-{4-[2-(Methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine. Molbank 2019, 2019, M1048.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop