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Open AccessShort Note

(E)-3-[3-(4-Morpholinophenyl)acryloyl]-2H-chromen-2-one

Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia
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Author to whom correspondence should be addressed.
Molbank 2018, 2018(4), M1027; https://doi.org/10.3390/M1027
Received: 23 September 2018 / Revised: 21 October 2018 / Accepted: 25 October 2018 / Published: 29 October 2018
(This article belongs to the Collection Molecules from Catalytic Processes)
A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS, 1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. View Full-Text
Keywords: molecular hybridization; coumarin-chalcone; anticancer molecular hybridization; coumarin-chalcone; anticancer
MDPI and ACS Style

Suwito, H.; Hardiyanti, H.D.; Ul Haq, K.; Kristanti, A.N.; Khasanah, M. (E)-3-[3-(4-Morpholinophenyl)acryloyl]-2H-chromen-2-one. Molbank 2018, 2018, M1027.

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