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Molbank 2018, 2018(4), M1027;


Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia
Author to whom correspondence should be addressed.
Received: 23 September 2018 / Revised: 21 October 2018 / Accepted: 25 October 2018 / Published: 29 October 2018
(This article belongs to the Special Issue Molecules from Catalytic Processes)
Full-Text   |   PDF [478 KB, uploaded 29 October 2018]


A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS, 1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. View Full-Text
Keywords: molecular hybridization; coumarin-chalcone; anticancer molecular hybridization; coumarin-chalcone; anticancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Suwito, H.; Hardiyanti, H.D.; Ul Haq, K.; Kristanti, A.N.; Khasanah, M. (E)-3-[3-(4-Morpholinophenyl)acryloyl]-2H-chromen-2-one. Molbank 2018, 2018, M1027.

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