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(E)-1-(2′,4′-Dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one

Department of Pharmaceutical Chemistry, Vignan Pharmacy College, Vadlamudi-522 213, Guntur, Andhra Pradesh, India
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Author to whom correspondence should be addressed.
Molbank 2018, 2018(3), M1019; https://doi.org/10.3390/M1019
Received: 27 August 2018 / Revised: 10 September 2018 / Accepted: 12 September 2018 / Published: 13 September 2018
(This article belongs to the Collection Molecules from Catalytic Processes)
Thiazole and chalcone motifs are of research interest to medicinal chemists due to their array of synthetic and biological utility. Hence, in the present study we intended to prepare (E)-1-(2′,4′-dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one (3c) containing both these scaffolds. The compound 3c was synthesized by the acid-catalyzed condensation of 2,4-dimethyl-5-acetylthiazole with 2,4-difluorobenzaldehyde. Purification and characterization of the compound were carried out by recrystallization and spectral techniques including UV, IR, 1H-NMR, 13C-NMR, Mass spectrometry and X-ray powdered diffractometry. The molecule 3c was successfully synthesized, purified, and characterized. View Full-Text
Keywords: thiazole; chalcone; acid-catalyzed condensation; (E)-1-(2′,4′-dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one thiazole; chalcone; acid-catalyzed condensation; (E)-1-(2′,4′-dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one
MDPI and ACS Style

Shaik, A.; Shaik, M.S.; Puttagunta, S.B. (E)-1-(2′,4′-Dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one. Molbank 2018, 2018, M1019.

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