(1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Information
3.2. Synthesis of (1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one (9)
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Entry | Lewis Acid a | Temperature | Solvent | Yields of 7 b | Yields of 9 b |
---|---|---|---|---|---|
1 | BF3·Et2O | 25 °C | EtOAc | 90% | 1% |
2 | LiCl | 25 °C | EtOAc | 33% | 60% |
3 | LiCl | 25 °C | EtOH | 1% | 92% |
4 | ZnCl2 | 25 °C | EtOAc | 29% | 65% |
5 | FeCl3 | 25 °C | EtOAc | 46% | 42% |
6 | Yb(OTf)3 | 25 °C | EtOAc | 56% | 36% |
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Fu, D.-J.; Pham, V.; Tippin, M.-A.; Song, L.; Zi, X.; Zhang, E.; Liu, H.-M. (1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one. Molbank 2018, 2018, M1016. https://doi.org/10.3390/M1016
Fu D-J, Pham V, Tippin M-A, Song L, Zi X, Zhang E, Liu H-M. (1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one. Molbank. 2018; 2018(3):M1016. https://doi.org/10.3390/M1016
Chicago/Turabian StyleFu, Dong-Jun, Victor Pham, Matthew-Alexander Tippin, Liankun Song, Xiaolin Zi, En Zhang, and Hong-Min Liu. 2018. "(1R,5S)-6-(4-Methyl-2-oxo-2,5-dihydrofuran-3-yl)-3-phenyl-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-en-7-one" Molbank 2018, no. 3: M1016. https://doi.org/10.3390/M1016