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Int. J. Mol. Sci. 2008, 9(6), 1096-1107;

Betulinic Acid for Cancer Treatment and Prevention

University Children’s Hospital, Eythstr. 24, 89075 Ulm, Germany
Published: 27 June 2008
(This article belongs to the Special Issue Natural Compounds for Cancer Treatment and Prevention)
Full-Text   |   PDF [297 KB, uploaded 19 June 2014]


Betulinic acid is a natural product with a range of biological effects, for example potent antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell death in cancer cells by triggering the mitochondrial pathway of apoptosis. In contrast to the cytotoxicity of betulinic acid against a variety of cancer types, normal cells and tissue are relatively resistant to betulinic acid, pointing to a therapeutic window. Compounds that exert a direct action on mitochondria present promising experimental cancer therapeutics, since they may trigger cell death under circumstances in which standard chemotherapeutics fail. Thus, mitochondrion-targeted agents such as betulinic acid hold great promise as a novel therapeutic strategy in the treatment of human cancers. View Full-Text
Keywords: apoptosis; cancer; betulinic acid; mitochondria apoptosis; cancer; betulinic acid; mitochondria
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fulda, S. Betulinic Acid for Cancer Treatment and Prevention. Int. J. Mol. Sci. 2008, 9, 1096-1107.

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