Next Article in Journal
Alterations in the Components of the GABA–Glutamate System During ZIKV Infection: A Neuroscience Approach
Previous Article in Journal
Association of Genetic Variants in PNPLA3, MBOAT7, and MARC1 with Metabolic and Hematological Immune-Inflammation Indices in Adolescent Females with and Without MASLD: A Multilevel Risk-Allele Burden Analysis
Previous Article in Special Issue
Diagnostic and Prognostic Potential of CXCL9 and CXCL10 Chemokines in Alcohol-Associated Liver Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 27
Issue 11
10.3390/ijms27114839
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Neutrophils and Neutrophil Extracellular Traps in Hepatic Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Strategies

by
Furong Xu
1,
Meiyan Wang
2,
Bingxin Wang
2,
Jian Yang
1,* and
Xiaoqing Qian
3,4,5,*
1
Department of Emergency, The First Affiliated Hospital of Shihezi University, Shihezi 832000, China
2
School of Medicine, Shihezi University, Shihezi 832000, China
3
School of Pharmacy, Shihezi University, Shihezi 832003, China
4
Key Laboratory of Xinjiang Phytomedicine Resources and Utilization, Ministry of Education, Shihezi 832003, China
5
Collaborative Innovation Center for Efficient Production and Resource Utilization of Safflower, Institute for Safflower Industry Research of Shihezi University, Shihezi 832003, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(11), 4839; https://doi.org/10.3390/ijms27114839
Submission received: 8 April 2026 / Revised: 5 May 2026 / Accepted: 9 May 2026 / Published: 27 May 2026
(This article belongs to the Special Issue Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target)
Review Reports Versions Notes

Abstract

Hepatic ischemia–reperfusion injury (HIRI) is an unavoidable clinical challenge in liver transplantation, major hepatectomy and trauma resuscitation, with no approved specific therapeutics to date. As core innate immune effector cells, neutrophils are the central driver of the sterile inflammatory cascade in HIRI. Centered on the Mac-1-Syk core regulatory axis, this review systematically elaborates the neutrophil recruitment cascade and intracellular signaling network in HIRI, focuses on the sequential formation pathways of neutrophil extracellular traps (NETs) and their multi-dimensional injury mechanisms, and dissects the inflammation–thrombosis amplification crosstalk between neutrophils and multiple hepatic non-parenchymal cells. Furthermore, this review clarifies research controversies of core therapeutic targets, analyzes key translational bottlenecks, and proposes a NETs-centered sequential multi-target combination strategy, providing a solid theoretical basis and clear translational direction for the precise targeted therapy of HIRI.
Keywords: hepatic ischemia–reperfusion injury (HIRI); neutrophils; neutrophil extracellular traps (NETs); sterile inflammation; targeted therapy hepatic ischemia–reperfusion injury (HIRI); neutrophils; neutrophil extracellular traps (NETs); sterile inflammation; targeted therapy

Share and Cite

MDPI and ACS Style

Xu, F.; Wang, M.; Wang, B.; Yang, J.; Qian, X. Neutrophils and Neutrophil Extracellular Traps in Hepatic Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Strategies. Int. J. Mol. Sci. 2026, 27, 4839. https://doi.org/10.3390/ijms27114839

AMA Style

Xu F, Wang M, Wang B, Yang J, Qian X. Neutrophils and Neutrophil Extracellular Traps in Hepatic Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Strategies. International Journal of Molecular Sciences. 2026; 27(11):4839. https://doi.org/10.3390/ijms27114839

Chicago/Turabian Style

Xu, Furong, Meiyan Wang, Bingxin Wang, Jian Yang, and Xiaoqing Qian. 2026. "Neutrophils and Neutrophil Extracellular Traps in Hepatic Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Strategies" International Journal of Molecular Sciences 27, no. 11: 4839. https://doi.org/10.3390/ijms27114839

APA Style

Xu, F., Wang, M., Wang, B., Yang, J., & Qian, X. (2026). Neutrophils and Neutrophil Extracellular Traps in Hepatic Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Strategies. International Journal of Molecular Sciences, 27(11), 4839. https://doi.org/10.3390/ijms27114839

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop