Next Article in Journal
Elevated Cardiac Troponin in Non-Cardiac Conditions Unrelated to Acute Myocardial Infarction
Previous Article in Journal
Proteome-Based Biomarkers for Alzheimer’s Disease: Old Acquisitions and Innovative Proposals
Previous Article in Special Issue
Paradoxical Psoriasis in Patients Receiving Therapy with Tumor Necrosis Factor Inhibitors: Potential Pathogenic Mechanisms and the Role of Genetic Factors
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 23
10.3390/ijms262311652
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Lights and Shadows of Nutrient-Driven Keratinocyte Inflammation in Psoriasis

by
Desirèe Speranza
1,†,
Alice Pantano
1,†,
Chiara Cullotta
2,
Giovanni Pallio
2,
Mario Vaccaro
1,*,
Michele Scuruchi
1,‡ and
Natasha Irrera
1,‡
1
Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy
2
Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Via C. Valeria, 98125 Messina, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors also contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(23), 11652; https://doi.org/10.3390/ijms262311652 (registering DOI)
Submission received: 9 October 2025 / Revised: 18 November 2025 / Accepted: 28 November 2025 / Published: 1 December 2025
(This article belongs to the Special Issue Psoriasis: Molecular Research and Novel Therapy)
Versions Notes

Abstract

Priasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation, impaired differentiation, and dysregulated immune responses. Emerging evidence highlights the central role of keratinocytes as immune-competent cells that integrate signals from cytokines, metabolic cues, the gut–skin axis, and the tissue microenvironment. Key intracellular signaling pathways, including NF-κB, JAK/STAT, MAPK, and PI3K/AKT/mTOR, along with the IL-23/IL-17 axis, orchestrate keratinocyte-mediated inflammation and epidermal hyperplasia. Metabolic factors, nutrients, and redox balance further modulate these responses, while the intestinal microbiota and its metabolites, such as short-chain fatty acids, shape systemic and cutaneous inflammation. This review offers a critical, integrated perspective, that moves beyond descriptive summaries. We propose a conceptual framework in which the keratinocyte metabolic state, particularly the sirtuin/NAD+ axis, acts as a crucial convergence point for systemic nutritional, microbial, and inflammatory signals. Targeting sirtuins and associated pathways with natural or synthetic modulators represents a promising, host-centric strategy to restore keratinocyte function and reduce chronic inflammation. This synthesis underscores the potential of combining molecular, metabolic, microbial, and nutritional insights to develop personalized and effective approaches for psoriasis management. 
Keywords: Psoriasis; keratinocyte; gut–skin axis; nutrient metabolism; oxidative stress Psoriasis; keratinocyte; gut–skin axis; nutrient metabolism; oxidative stress

Share and Cite

MDPI and ACS Style

Speranza, D.; Pantano, A.; Cullotta, C.; Pallio, G.; Vaccaro, M.; Scuruchi, M.; Irrera, N. Lights and Shadows of Nutrient-Driven Keratinocyte Inflammation in Psoriasis. Int. J. Mol. Sci. 2025, 26, 11652. https://doi.org/10.3390/ijms262311652

AMA Style

Speranza D, Pantano A, Cullotta C, Pallio G, Vaccaro M, Scuruchi M, Irrera N. Lights and Shadows of Nutrient-Driven Keratinocyte Inflammation in Psoriasis. International Journal of Molecular Sciences. 2025; 26(23):11652. https://doi.org/10.3390/ijms262311652

Chicago/Turabian Style

Speranza, Desirèe, Alice Pantano, Chiara Cullotta, Giovanni Pallio, Mario Vaccaro, Michele Scuruchi, and Natasha Irrera. 2025. "Lights and Shadows of Nutrient-Driven Keratinocyte Inflammation in Psoriasis" International Journal of Molecular Sciences 26, no. 23: 11652. https://doi.org/10.3390/ijms262311652

APA Style

Speranza, D., Pantano, A., Cullotta, C., Pallio, G., Vaccaro, M., Scuruchi, M., & Irrera, N. (2025). Lights and Shadows of Nutrient-Driven Keratinocyte Inflammation in Psoriasis. International Journal of Molecular Sciences, 26(23), 11652. https://doi.org/10.3390/ijms262311652

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop