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Volume 26
Issue 23
10.3390/ijms262311269
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Review
Peer-Review Record

Salivary Oxidative Stress Biomarkers in Peri-Implant Disease: A Systematic Review and Meta-Analysis

Int. J. Mol. Sci. 2025, 26(23), 11269; https://doi.org/10.3390/ijms262311269
by Paul Șerban Popa, Gabriel Valeriu Popa *, Kamel Earar, Claudia Elisabeta Popa-Cazacu and Mădălina Nicoleta Matei
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2025, 26(23), 11269; https://doi.org/10.3390/ijms262311269
Submission received: 9 October 2025 / Revised: 12 November 2025 / Accepted: 14 November 2025 / Published: 21 November 2025
(This article belongs to the Special Issue Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Abstract requires some modifications

Refs of Fig 1???

PICOS model, Refs???

Eligibility Criteria, Refs???

Remove the sub-Sections from Discussion Section

Remove the parts of the text (464-480, and 483-496), as they contain irrelevant data

Refs of Fig. 9???

Conclusion(s) Section: Reduce, and state the main outcomes only....

 

 

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The paper ”Salivary Oxidative Stress Biomarkers in Peri-Implant Disease: 2 A Systematic Review and Meta-Analysis 3” by Popa P.S. et al. focuses on evaluating whether salivary malondialdehyde and total antioxidant capacity are associated with peri-implant disease. The manuscript is well organized, and all the criteria for a systematic review have been followed. Nevertheless, there are some issues that I need to address:

  • the quality of the figures included in the manuscript is quite low, and it needs to be improved
  • on lines 61-68 of the introduction section, the authors comment on results obtained in previous studies regarding other oxidative stress biomarkers than the one included in the present article. I think that that part should be removed, as it is not needed.
  • the conclusion section is too long. I recommend summarizing the information.
  • the 12 articles included in the analysis are not cited in the reference section
  • perhaps figures 1 and 9 could be combined, as they contain similar parts
  • minor spelling check should be performed. For example in figure 1 defanse should be corrected and replaces with denfese

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

In my opinion, the manuscript has been improved by the authors during the revision process, and I agree with its publication.

Author Response

Dear Reviewer,

We thank you very much for your suggestions; they have improved our manuscript considerably. 

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