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Volume 25
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10.3390/ijms25042134
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Review

Plant-Origin Components: New Players to Combat Antibiotic Resistance in Klebsiella pneumoniae

by
Victor M. Luna-Pineda
1,2,
Griselda Rodríguez-Martínez
1,2,
Marcela Salazar-García
3 and
Mariana Romo-Castillo
4,*
1
Laboratorio de Investigación en COVID-19, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico
2
Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico
3
Departamento de Investigación Biomédica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico
4
IxM/CONAHCYT-HIMFG, Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(4), 2134; https://doi.org/10.3390/ijms25042134
Submission received: 1 December 2023 / Revised: 9 January 2024 / Accepted: 13 January 2024 / Published: 10 February 2024
(This article belongs to the Special Issue Recent Research on Antimicrobial Agents)
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Abstract

Klebsiella pneumoniae (Kpn) is an opportunistic pathogen that causes intrahospital complications such as pneumonia, liver abscesses, soft tissue infections, urinary infections, bacteraemia, and, in some cases, death. Since this bacterium has a higher frequency than other Gram-negative pathogens, it has become an important pathogen to the health sector. The adaptative genome of Kpn likely facilitates increased survival of the pathogen in diverse situations. Therefore, several studies have been focused on developing new molecules, synergistic formulations, and biomaterials that make it possible to combat and control infections with and dispersion of this pathogen. Note that the uncontrolled antibiotic administration that occurred during the pandemic led to the emergence of new multidrug-resistant strains, and scientists were challenged to overcome them. This review aims to compile the latest information on Kpn that generates intrahospital infections, specifically their pathogenicity-associated factors. Furthermore, it explains the natural-product-based treatments (extracts and essential oils) developed for Kpn infection and dispersion control.
Keywords: Klebsiella pneumoniae; virulence factors; antibiotic resistance; plant-origin compounds; essential oils; plant extracts; treatment design Klebsiella pneumoniae; virulence factors; antibiotic resistance; plant-origin compounds; essential oils; plant extracts; treatment design

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MDPI and ACS Style

Luna-Pineda, V.M.; Rodríguez-Martínez, G.; Salazar-García, M.; Romo-Castillo, M. Plant-Origin Components: New Players to Combat Antibiotic Resistance in Klebsiella pneumoniae. Int. J. Mol. Sci. 2024, 25, 2134. https://doi.org/10.3390/ijms25042134

AMA Style

Luna-Pineda VM, Rodríguez-Martínez G, Salazar-García M, Romo-Castillo M. Plant-Origin Components: New Players to Combat Antibiotic Resistance in Klebsiella pneumoniae. International Journal of Molecular Sciences. 2024; 25(4):2134. https://doi.org/10.3390/ijms25042134

Chicago/Turabian Style

Luna-Pineda, Victor M., Griselda Rodríguez-Martínez, Marcela Salazar-García, and Mariana Romo-Castillo. 2024. "Plant-Origin Components: New Players to Combat Antibiotic Resistance in Klebsiella pneumoniae" International Journal of Molecular Sciences 25, no. 4: 2134. https://doi.org/10.3390/ijms25042134

APA Style

Luna-Pineda, V. M., Rodríguez-Martínez, G., Salazar-García, M., & Romo-Castillo, M. (2024). Plant-Origin Components: New Players to Combat Antibiotic Resistance in Klebsiella pneumoniae. International Journal of Molecular Sciences, 25(4), 2134. https://doi.org/10.3390/ijms25042134

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