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Volume 25
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10.3390/ijms252111714
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Article

Autocrine Motility Factor and Its Peptide Derivative Inhibit Triple-Negative Breast Cancer by Regulating Wound Repair, Survival, and Drug Efflux

by
Se Gie Kim
1,†,
Seok Joong Kim
2,†,
Thanh Van Duong
3,
Yuhan Cho
4,
Bogeun Park
4,
Ulhas Sopanrao Kadam
4,
Hee Sung Park
4,* and
Jong Chan Hong
4,*
1
Department of Cosmetic Science, Kyungsung University, Busan 48434, Republic of Korea
2
Department of Food and Nutrition, College of Natural and Information Science, Dongduk Women’s University, Seoul 02758, Republic of Korea
3
Department of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea
4
Division of Applied Life Science (BK21 Four), Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 52828, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(21), 11714; https://doi.org/10.3390/ijms252111714
Submission received: 30 September 2024 / Revised: 25 October 2024 / Accepted: 29 October 2024 / Published: 31 October 2024
(This article belongs to the Special Issue Molecular Signatures of Gynecological Cancers—Breast Cancer, Ovarian Cancer, Cervical Cancer, and Endometrial Cancer 2.0)
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Abstract

Triple-negative breast cancer (TNBC) presents a significant challenge in oncology due to its aggressive nature and limited targeted therapeutic options. This study explores the potential of autocrine motility factor (AMF) and an AMF-derived peptide as novel treatments for TNBC. AMF, primarily secreted by neoplastic cells, plays a crucial role in cancer cell motility, metastasis, and proliferation. The research demonstrates that AMF and its derived peptide inhibit TNBC cell proliferation by modulating cellular migration, redox homeostasis, apoptotic pathways, and drug efflux mechanisms. Dose-dependent antiproliferative effects were observed across three TNBC cell lines, with higher concentrations impairing cellular migration. Mechanistic studies revealed decreased glucose-6-phosphate dehydrogenase expression and elevated reactive oxygen species production, suggesting redox imbalance as a primary mediator of apoptosis. Combination studies with conventional therapeutics showed near-complete eradication of resistant TNBC cells. The observed reduction in p53 levels and increased intranuclear doxorubicin accumulation highlight the AMF/AMF peptide’s potential as multidrug resistance modulators. This study underscores the promise of using AMF/AMF peptide as a novel therapeutic approach for TNBC, addressing current treatment limitations and warranting further investigation.
Keywords: apoptosis; autocrine motility factor; drug accumulation; resistance; triple-negative breast cancer apoptosis; autocrine motility factor; drug accumulation; resistance; triple-negative breast cancer

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MDPI and ACS Style

Kim, S.G.; Kim, S.J.; Duong, T.V.; Cho, Y.; Park, B.; Kadam, U.S.; Park, H.S.; Hong, J.C. Autocrine Motility Factor and Its Peptide Derivative Inhibit Triple-Negative Breast Cancer by Regulating Wound Repair, Survival, and Drug Efflux. Int. J. Mol. Sci. 2024, 25, 11714. https://doi.org/10.3390/ijms252111714

AMA Style

Kim SG, Kim SJ, Duong TV, Cho Y, Park B, Kadam US, Park HS, Hong JC. Autocrine Motility Factor and Its Peptide Derivative Inhibit Triple-Negative Breast Cancer by Regulating Wound Repair, Survival, and Drug Efflux. International Journal of Molecular Sciences. 2024; 25(21):11714. https://doi.org/10.3390/ijms252111714

Chicago/Turabian Style

Kim, Se Gie, Seok Joong Kim, Thanh Van Duong, Yuhan Cho, Bogeun Park, Ulhas Sopanrao Kadam, Hee Sung Park, and Jong Chan Hong. 2024. "Autocrine Motility Factor and Its Peptide Derivative Inhibit Triple-Negative Breast Cancer by Regulating Wound Repair, Survival, and Drug Efflux" International Journal of Molecular Sciences 25, no. 21: 11714. https://doi.org/10.3390/ijms252111714

APA Style

Kim, S. G., Kim, S. J., Duong, T. V., Cho, Y., Park, B., Kadam, U. S., Park, H. S., & Hong, J. C. (2024). Autocrine Motility Factor and Its Peptide Derivative Inhibit Triple-Negative Breast Cancer by Regulating Wound Repair, Survival, and Drug Efflux. International Journal of Molecular Sciences, 25(21), 11714. https://doi.org/10.3390/ijms252111714

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