Next Article in Journal
Immunophenotypical Characterization of Limbal Mesenchymal Stromal Cell Subsets during In Vitro Expansion
Next Article in Special Issue
Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study
Previous Article in Journal
In Vitro Effect of Epigallocatechin Gallate on Heme Synthesis Pathway and Protoporphyrin IX Production
Previous Article in Special Issue
Chronic Epinephrine-Induced Endoplasmic Reticulum and Oxidative Stress Impairs Pancreatic β-Cells Function and Fate
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 25
Issue 16
10.3390/ijms25168682
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types

by
Anna Klimont
1,
Marcin Ruciński
2,
Nadia Sawicka-Gutaj
1,
Marta Szyszka
2,
Małgorzata Blatkiewicz
2,
Tomasz Wierzbicki
3,
Marek Karczewski
4,
Małgorzata Janicka-Jedyńska
5,
Marek Ruchała
1 and
Hanna Komarowska
1,*
1
Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-356 Poznan, Poland
2
Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland
3
Department of General, Endocrinological and Gastroenterological Surgery, Poznan University of Medical Sciences, 60-355 Poznan, Poland
4
Department of General and Transplantation Surgery, Poznan University of Medical Sciences, 60-356 Poznan, Poland
5
Department of Clinical Pathology, Poznan University of Medical Sciences, 60-356 Poznan, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(16), 8682; https://doi.org/10.3390/ijms25168682
Submission received: 27 June 2024 / Revised: 3 August 2024 / Accepted: 7 August 2024 / Published: 9 August 2024
(This article belongs to the Special Issue Advanced Research on the Adrenal Gland and Hormones)
Browse Figures
Review Reports Versions Notes

Abstract

The aim of the study was to evaluate the diagnostic and prognostic significance of leptin receptor isoforms in adrenal tumors. In a single-center study, 96 patients (19 with adrenal cortical carcinoma and 77 with benign tumors) underwent an adrenalectomy. A total of 14 unaffected adrenal gland tissues from kidney donors were used as controls. Fasting blood samples were collected for laboratory tests, and mRNA expressions of leptin receptor isoforms were assessed by RT-qPCR. The study analyzed correlations between mRNA expressions and clinical data and measured NCI-H295R cell proliferation via a real-time cell analyzer. All adrenal lesions expressed leptin receptor isoforms. Significantly lower LepR1 expression was observed in carcinoma tissues than in adenomas and controls (p = 0.016). Expressions of LepR3&LepR6 were correlated with overall survival (p = 0.036), while LepR2&LepR4 and LepR5 expressions were inversely related to morning serum cortisol levels (p = 0.041). Leptin reduced NCI-H295R cell proliferation (p < 0.0001). The study highlights the diagnostic and prognostic significance of leptin receptor isoforms in adrenal tumors. Specifically, LepR1 may serve as a diagnostic marker for carcinomas, while LepR3&LepR6 have potential use as prognostic markers.
Keywords: leptin; adrenal carcinoma; ACC; leptin receptor isoforms; steroidogenesis leptin; adrenal carcinoma; ACC; leptin receptor isoforms; steroidogenesis

Share and Cite

MDPI and ACS Style

Klimont, A.; Ruciński, M.; Sawicka-Gutaj, N.; Szyszka, M.; Blatkiewicz, M.; Wierzbicki, T.; Karczewski, M.; Janicka-Jedyńska, M.; Ruchała, M.; Komarowska, H. Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types. Int. J. Mol. Sci. 2024, 25, 8682. https://doi.org/10.3390/ijms25168682

AMA Style

Klimont A, Ruciński M, Sawicka-Gutaj N, Szyszka M, Blatkiewicz M, Wierzbicki T, Karczewski M, Janicka-Jedyńska M, Ruchała M, Komarowska H. Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types. International Journal of Molecular Sciences. 2024; 25(16):8682. https://doi.org/10.3390/ijms25168682

Chicago/Turabian Style

Klimont, Anna, Marcin Ruciński, Nadia Sawicka-Gutaj, Marta Szyszka, Małgorzata Blatkiewicz, Tomasz Wierzbicki, Marek Karczewski, Małgorzata Janicka-Jedyńska, Marek Ruchała, and Hanna Komarowska. 2024. "Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types" International Journal of Molecular Sciences 25, no. 16: 8682. https://doi.org/10.3390/ijms25168682

APA Style

Klimont, A., Ruciński, M., Sawicka-Gutaj, N., Szyszka, M., Blatkiewicz, M., Wierzbicki, T., Karczewski, M., Janicka-Jedyńska, M., Ruchała, M., & Komarowska, H. (2024). Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types. International Journal of Molecular Sciences, 25(16), 8682. https://doi.org/10.3390/ijms25168682

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop