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Volume 25
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Review

Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin–Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions

by
Nadia Khan
1,2,†,
Magdalena Kurnik-Łucka
1,*,†,
Gniewomir Latacz
2 and
Krzysztof Gil
1
1
Faculty of Medicine, Department of Pathophysiology, Jagiellonian University Medical College, Czysta 18, 31-121 Krakow, Poland
2
Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, 31-008 Krakow, Poland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(10), 5566; https://doi.org/10.3390/ijms25105566
Submission received: 17 April 2024 / Revised: 12 May 2024 / Accepted: 18 May 2024 / Published: 20 May 2024
(This article belongs to the Special Issue Role of Dopamine in Health and Disease: Biological Aspect 2.0)
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Abstract

In the first part of this article, the role of intestinal epithelial tight junctions (TJs), together with gastrointestinal dopaminergic and renin–angiotensin systems, are narratively reviewed to provide sufficient background. In the second part, the current experimental data on the interplay between gastrointestinal (GI) dopaminergic and renin–angiotensin systems in the regulation of intestinal epithelial permeability are reviewed in a systematic manner using the PRISMA methodology. Experimental data confirmed the copresence of DOPA decarboxylase (DDC) and angiotensin converting enzyme 2 (ACE2) in human and rodent enterocytes. The intestinal barrier structure and integrity can be altered by angiotensin (1-7) and dopamine (DA). Both renin–angiotensin and dopaminergic systems influence intestinal Na+/K+-ATPase activity, thus maintaining electrolyte and nutritional homeostasis. The colocalization of B0AT1 and ACE2 indicates the direct role of the renin–angiotensin system in amino acid absorption. Yet, more studies are needed to thoroughly define the structural and functional interaction between TJ-associated proteins and GI renin–angiotensin and dopaminergic systems.
Keywords: ACE2; dopamine; DDC; DOPA decarboxylase; angiotensin (1-7); Na+/K+-ATPase; B0AT1; tight junctions; gastrointestinal; leaky gut ACE2; dopamine; DDC; DOPA decarboxylase; angiotensin (1-7); Na+/K+-ATPase; B0AT1; tight junctions; gastrointestinal; leaky gut

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MDPI and ACS Style

Khan, N.; Kurnik-Łucka, M.; Latacz, G.; Gil, K. Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin–Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions. Int. J. Mol. Sci. 2024, 25, 5566. https://doi.org/10.3390/ijms25105566

AMA Style

Khan N, Kurnik-Łucka M, Latacz G, Gil K. Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin–Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions. International Journal of Molecular Sciences. 2024; 25(10):5566. https://doi.org/10.3390/ijms25105566

Chicago/Turabian Style

Khan, Nadia, Magdalena Kurnik-Łucka, Gniewomir Latacz, and Krzysztof Gil. 2024. "Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin–Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions" International Journal of Molecular Sciences 25, no. 10: 5566. https://doi.org/10.3390/ijms25105566

APA Style

Khan, N., Kurnik-Łucka, M., Latacz, G., & Gil, K. (2024). Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin–Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions. International Journal of Molecular Sciences, 25(10), 5566. https://doi.org/10.3390/ijms25105566

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