Next Article in Journal
Populus euphratica GLABRA3 Binds PLDδ Promoters to Enhance Salt Tolerance
Next Article in Special Issue
Fluorinated Benzofuran and Dihydrobenzofuran as Anti-Inflammatory and Potential Anticancer Agents
Previous Article in Journal
The Effectiveness of L-arginine in Clinical Conditions Associated with Hypoxia
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 24
Issue 9
10.3390/ijms24098207
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Arachidonic Acid Pathways and Male Fertility: A Systematic Review

by
Malvina Hoxha
1,*,
Arcangelo Barbonetti
2 and
Bruno Zappacosta
1
1
Department for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1000 Tirana, Albania
2
Andrology Unit, Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(9), 8207; https://doi.org/10.3390/ijms24098207
Submission received: 6 March 2023 / Revised: 23 April 2023 / Accepted: 25 April 2023 / Published: 3 May 2023
(This article belongs to the Special Issue Advances in Pharmacology of Prostaglandins)
Browse Figures
Versions Notes

Abstract

Arachidonic acid (AA) is a polyunsaturated fatty acid that is involved in male fertility. Human seminal fluid contains different prostaglandins: PGE (PGE1 and PGE2), PGF2α, and their specific 19-hydroxy derivatives, 18,19-dehydro derivatives of PGE1 and PGE2. The objective of this study is to synthesize the available literature of in vivo animal studies and human clinical trials on the association between the AA pathway and male fertility. PGE is significantly decreased in the semen of infertile men, suggesting the potential for exploitation of PGE agonists to improve male fertility. Indeed, ibuprofen can affect male fertility by promoting alterations in sperm function and standard semen parameters. The results showed that targeting the AA pathways could be an attractive strategy for the treatment of male fertility.
Keywords: male fertility; arachidonic acid pathway; prostaglandins male fertility; arachidonic acid pathway; prostaglandins

Share and Cite

MDPI and ACS Style

Hoxha, M.; Barbonetti, A.; Zappacosta, B. Arachidonic Acid Pathways and Male Fertility: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 8207. https://doi.org/10.3390/ijms24098207

AMA Style

Hoxha M, Barbonetti A, Zappacosta B. Arachidonic Acid Pathways and Male Fertility: A Systematic Review. International Journal of Molecular Sciences. 2023; 24(9):8207. https://doi.org/10.3390/ijms24098207

Chicago/Turabian Style

Hoxha, Malvina, Arcangelo Barbonetti, and Bruno Zappacosta. 2023. "Arachidonic Acid Pathways and Male Fertility: A Systematic Review" International Journal of Molecular Sciences 24, no. 9: 8207. https://doi.org/10.3390/ijms24098207

APA Style

Hoxha, M., Barbonetti, A., & Zappacosta, B. (2023). Arachidonic Acid Pathways and Male Fertility: A Systematic Review. International Journal of Molecular Sciences, 24(9), 8207. https://doi.org/10.3390/ijms24098207

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop